Nerve guidance conduit development for primary treatment of peripheral nerve transection injuries: A commercial perspective

BJ Parker, DI Rhodes, CM O'Brien, AE Rodda… - Acta Biomaterialia, 2021 - Elsevier
Commercial nerve guidance conduits (NGCs) for repair of peripheral nerve discontinuities
are of little use in gaps larger than 30 mm, and for smaller gaps they often fail to compete …

Advancing nerve regeneration: Translational perspectives of tacrolimus (FK506)

SC Daeschler, K Feinberg, L Harhaus… - International Journal of …, 2023 - mdpi.com
Peripheral nerve injuries have far-reaching implications for individuals and society, leading
to functional impairments, prolonged rehabilitation, and substantial socioeconomic burdens …

Electrical stimulation of human neural stem cells via conductive polymer nerve guides enhances peripheral nerve recovery

S Song, KW McConnell, D Amores, A Levinson… - Biomaterials, 2021 - Elsevier
Severe peripheral nerve injuries often result in permanent loss of function of the affected
limb. Current treatments are limited by their efficacy in supporting nerve regeneration and …

A systematic review and meta-analysis of nerve gap repair: comparative effectiveness of allografts, autografts, and conduits

J Lans, KR Eberlin, PJ Evans, D Mercer… - Plastic and …, 2023 - journals.lww.com
Background: Ideal nerve repair involves tensionless direct repair, which may not be possible
after resection. Bridging materials include nerve autograft, allograft, or conduit. This study …

Therapeutic low-intensity ultrasound for peripheral nerve regeneration–a schwann cell perspective

J Acheta, SBZ Stephens, S Belin… - Frontiers in Cellular …, 2022 - frontiersin.org
Peripheral nerve injuries are common conditions that can arise from trauma (eg,
compression, severance) and can lead to neuropathic pain as well as motor and sensory …

Biology and pathophysiology of symptomatic neuromas

CD Hwang, YAJ Hoftiezer, FV Raasveld… - Pain, 2024 - journals.lww.com
Neuromas are a substantial cause of morbidity and reduction in quality of life. This is not
only caused by a disruption in motor and sensory function from the underlying nerve injury …

Ti3C2Tx MXene-Coated Electrospun PCL Conduits for Enhancing Neurite Regeneration and Angiogenesis

LP Nan, Z Lin, F Wang, XH Jin, JQ Fang… - … in Bioengineering and …, 2022 - frontiersin.org
An electrical signal is the key basis of normal physiological function of the nerve, and the
stimulation of the electric signal also plays a very special role in the repair process of nerve …

[HTML][HTML] Exploring the molecular pathways and therapeutic implications of angiogenesis in neuropathic pain

A Sharma, T Behl, L Sharma, OP Shah, S Yadav… - Biomedicine & …, 2023 - Elsevier
Recently, much attention has been paid to chronic neuro-inflammatory condition underlying
neuropathic pain. It is generally linked with thermal hyperalgesia and tactile allodynia. It …

In Vitro, In Vivo and Ex Vivo Models for Peripheral Nerve Injury and Regeneration

A Li, C Pereira, EE Hill, O Vukcevich… - Current …, 2022 - benthamdirect.com
Peripheral Nerve Injuries (PNI) frequently occur secondary to traumatic injuries. Recovery
from these injuries can be expectedly poor, especially in proximal injuries. In order to study …

Incorporating blood flow in nerve injury and regeneration assessment

S Yeoh, WS Warner, SS Merchant, EW Hsu… - Frontiers in …, 2022 - frontiersin.org
Peripheral nerve injury is a significant public health challenge, with limited treatment options
and potential lifelong impact on function. More than just an intrinsic part of nerve anatomy …