The stress-inducible ER chaperone GRP78/BiP is upregulated during SARS-CoV-2 infection and acts as a pro-viral protein
The current Coronavirus global pandemic necessitates the search for novel targets and
therapeutic avenues. Shaban et al. 1 reported the use of an endoplasmic reticulum (ER) …
therapeutic avenues. Shaban et al. 1 reported the use of an endoplasmic reticulum (ER) …
[HTML][HTML] Strain wars 2: Binding constants, enthalpies, entropies, Gibbs energies and rates of binding of SARS-CoV-2 variants
M Popovic - Virology, 2022 - Elsevier
SARS-CoV-2 virus is the cause of COVID-19 pandemic and belongs to RNA viruses,
showing great tendency to mutate. Several dozens of mutations have been observed on the …
showing great tendency to mutate. Several dozens of mutations have been observed on the …
Omicron SARS-CoV-2 variant spike protein shows an increased affinity to the human ACE2 receptor: an in silico analysis
The rise of SARS-CoV-2 variants, with changes that could be related to an increased virus
pathogenicity, have received the interest of the scientific and medical community. In this …
pathogenicity, have received the interest of the scientific and medical community. In this …
Serum glucose-regulated protein 78 (GRP78) levels in COVID-19-associated mucormycosis: results of a case–control study
Background In experimental models, the expression of glucose-regulated protein 78
(GRP78) in endothelial cells played a role in the pathogenesis of mucormycosis. However …
(GRP78) in endothelial cells played a role in the pathogenesis of mucormycosis. However …
A Suitable Membrane Distance Regulated by the RBD_ACE2 Interaction is Critical for SARS‐CoV‐2 Spike‐Mediated Viral Invasion
M Wu, W Li, S Lin, J Fan, L Cui, Y Xiang, K Li… - Advanced …, 2023 - Wiley Online Library
The receptor‐binding domain (RBD) of spike recognizing the receptor angiotensin‐
converting enzyme 2 (ACE2) initiates membrane fusion between severe acute respiratory …
converting enzyme 2 (ACE2) initiates membrane fusion between severe acute respiratory …
Structural plasticity of omicron BA. 5 and BA. 2.75 for enhanced ACE-dependent entry into cells
J Lin, F Anjum Huma, A Irfan, SS Ali… - Journal of …, 2023 - Taylor & Francis
The current study investigated the binding variations among the wilt type, Omicron sub-
variants BA. 2.75 and BA. 5, using protein-protein docking, protein structural graphs (P SG) …
variants BA. 2.75 and BA. 5, using protein-protein docking, protein structural graphs (P SG) …
Prediction of viral-host interactions of COVID-19 by computational methods
TB Alakus, I Turkoglu - Chemometrics and Intelligent Laboratory Systems, 2022 - Elsevier
Experimental approaches are currently used to determine viral-host interactions, but these
approaches are both time-consuming and costly. For these reasons, computational-based …
approaches are both time-consuming and costly. For these reasons, computational-based …
Structural basis for the mechanism of interaction of SARS-CoV-2 B. 1.640. 2 variant RBD with the host receptors hACE2 and GRP78
A Shafiq, U Khalid, U Abdur Rehman… - Journal of …, 2024 - Taylor & Francis
The inflicted chaos instigated by the SARS-CoV-2 (Severe acute respiratory syndrome
coronavirus 2) globally continues with the emergence of novel variants. The current global …
coronavirus 2) globally continues with the emergence of novel variants. The current global …