Due to the growing number of young patients at risk of germ cell loss, there is a need to
preserve spermatogonial stem cells for patients who are not able to bank spermatozoa …

Abstract In 1963 George Mathé announced to the world that he had cured a patient of
leukaemia by means of a bone-marrow transplant. Since than much progress has been …

Sustained donor engraftment after allogeneic hematopoietic cell transplantation (HCT)
converts to healthy donor hemoglobin synthesis and halts disease symptoms in patients with …

Women with β-thalassemia (BT) and sickle cell disease (SCD) have a high risk of infertility
and premature ovarian insufficiency. Different fertility preserving strategies, including …

In the not so distant past, pregnancy for women with transfusion-dependent thalassemia
(TDT) was considered very high risk and often not recommended. As management of these …

Zinc fluctuations regulate key steps in late oocyte and preimplantation embryo development;
however, roles for zinc in preceding stages in early ovarian follicle development, when …

Abstract β-thalassaemia major (BTM) has a high prevalence worldwide and is associated
with considerable morbidity and mortality. The aim of this review is to provide an illustrative …

Background: The treatment of endocrinopathies in haemoglobinopathies is a continually
expanding research area; therefore, recommendations supporting the appropriateness of …

The aim of this study was to investigate the methods of conception and delivery, as well as
the course and outcome of 42 pregnancies occurring in 15 female patients (27 pregnancies) …

Background Despite the significant advances in thalassemia pathobiology and efficacy of
chelation regimens, complications of transfusion therapy have attenuated the reproductive …