Emerging trends in micro-and nanoscale technologies in medicine: From basic discoveries to translation

MM Alvarez, J Aizenberg, M Analoui, AM Andrews… - ACS …, 2017 - ACS Publications
We discuss the state of the art and innovative micro-and nanoscale technologies that are
finding niches and opening up new opportunities in medicine, particularly in diagnostic and …

An update on antiviral antibody-based biopharmaceuticals

S Ahangarzadeh, Z Payandeh, R Arezumand… - International …, 2020 - Elsevier
Due to the vastness of the science virology, it is no longer an offshoot solely of the
microbiology. Viruses have become as the causative agents of major epidemics throughout …

A digital–analog microfluidic platform for patient-centric multiplexed biomarker diagnostics of ultralow volume samples

F Piraino, F Volpetti, C Watson, SJ Maerkl - ACS nano, 2016 - ACS Publications
Microfluidic diagnostic devices have the potential to transform the practice of medicine. We
engineered a multiplexed digital–analog microfluidic platform for the rapid and highly …

Supramolecular fluorogenic peptide sensor array based on graphene oxide for the differential sensing of ebola virus

MQ Fu, XC Wang, WT Dou, GR Chen… - Chemical …, 2020 - pubs.rsc.org
We report on a supramolecular sensor array using fluorogenic peptide probes and
graphene oxide that can target glycoproteins on a viral caspid, facilitating the differentiation …

Serological test to determine exposure to SARS-CoV-2: ELISA based on the receptor-binding domain of the spike protein (S-RBDN318-V510) expressed in …

AR Márquez-Ipiña, E González-González… - Diagnostics, 2021 - mdpi.com
Massive worldwide serological testing for SARS-CoV-2 is needed to determine the extent of
virus exposure in a particular region, the ratio of symptomatic to asymptomatic infected …

Optimization of methods for the production and refolding of biologically active disulfide bond-rich antibody fragments in microbial hosts

B Ban, M Sharma, J Shetty - Antibodies, 2020 - mdpi.com
Antibodies have been used for basic research, clinical diagnostics, and therapeutic
applications. Escherichia coli is one of the organisms of choice for the production of …

Anti-Ebola therapies based on monoclonal antibodies: current state and challenges ahead

E González-González, MM Alvarez… - Critical reviews in …, 2017 - Taylor & Francis
The 2014 Ebola outbreak, the largest recorded, took us largely unprepared, with no
available vaccine or specific treatment. In this context, the World Health Organization …

Development of a bead-based immunoassay using virus-like particles for detection of alphaviral humoral response

KM Ricks, CJ Shoemaker, LC Dupuy, O Flusin… - Journal of virological …, 2019 - Elsevier
There is a pressing need for sustainable and sensitive immunodiagnostics for use in public
health efforts to understand and combat the threat of endemic and emerging infectious …

Molecular modeling and simulation tools in the development of peptide-based biosensors for mycotoxin detection: Example of ochratoxin

AA Thyparambil, I Bazin, A Guiseppi-Elie - Toxins, 2017 - mdpi.com
Mycotoxin contamination of food and feed is now ubiquitous. Exposures to mycotoxin via
contact or ingestion can potentially induce adverse health outcomes. Affordable mycotoxin …

Gene transfer of ZMapp antibodies mediated by recombinant adeno-associated virus protects against Ebola infections

MA Robert, N Nassoury, PS Chahal… - Human Gene …, 2018 - liebertpub.com
Vectored delivery of the ZMapp antibody cocktail (c2G4, c4G7, and c13C6) by using
recombinant adeno-associated viruses (rAAVs) could be useful for preventive immunization …