Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Use of model organisms in aging research is problematic because our ability to extrapolate
across the tree of life is not clear. On one hand, there are conserved pathways that regulate …

The cytoprotective transcriptor factor nuclear factor erythroid 2–related factor 2 (NRF2) is
part of a complex regulatory network that responds to environmental cues. To better …

Among several theories to explain the complicated process of human ageing, the
mitochondrial oxidative stress hypothesis has received recent attention. Considering that …

Adult stem cells (ASCs) in vertebrates and model invertebrates (eg Drosophila
melanogaster) are typically long‐lived, lineage‐restricted, clonogenic and quiescent cells …

Delineating the physiological and biochemical causes of aging process in the animal
kingdom is a highly active area of research not only because of potential benefits for human …

Ageing is the time-dependent gradual decline of the functional characteristics in an
organism. It has been shown that it results in the loss of reproductive health and fertility. The …

The ability of animals to cope with environmental stress depends–in part–on past
experience, yet knowledge of the factors influencing an individual's physiology in nature …

The freshwater pearl mussel Margaritifera margaritifera is one of the most threatened
freshwater bivalves worldwide. In this study, we aimed (i) to study the processes by which …

Proteome damage plays a major role in aging and age-related neurodegenerative diseases.
Under healthy conditions, molecular quality control mechanisms prevent toxic protein …