A past history of pulmonary tuberculosis (TB) is a risk factor for long-term respiratory
impairment. Post-TB lung dysfunction often goes unrecognised, despite its relatively high …

▪ Abstract The matrix metalloproteinases (MMPs) constitute a multigene family of over 25
secreted and cell surface enzymes that process or degrade numerous pericellular …

Systematic sequencing of human cancer genomes has identified many recurrent mutations
in the protein-coding regions of genes but rarely in gene regulatory regions. Here, we …

For more than two decades, the view that tumour-associated matrix metalloproteinases
(MMPs) were required for peritumour tissue degradation and metastasis dominated the drive …

Abstract Matrix metalloproteinase (MMP)-1, MMP-8 and MMP-13 are interstitial
collagenases that degrade type II collagen in cartilage; this is a committed step in the …

It is 40 years since the first member of what came to be known as the matrix
metalloproteinase (MMP) family was described. Structural, molecular and biochemical …

Matrix metalloproteinases (MMPs) form a family of enzymes that mediate multiple functions
both in the tissue destruction and immune responses related to periodontal inflammation …

The metalloproteinases degrade extracellular matrix (ECM) components and activate growth
factors, thereby contributing to physiological events (tissue remodeling in pregnancy, wound …

Matrix metalloproteinases (MMPs) are the major protease family responsible for the
cleavage of the matrisome (global composition of the extracellular matrix (ECM) proteome) …

Matrix metalloproteinases (MMPs) are invariably upregulated in the stromal compartment of
epithelial cancers and appear to promote invasion and metastasis. Here we report that …