Macrophage immunometabolism in inflammatory bowel diseases: from pathogenesis to therapy

X Pan, Q Zhu, LL Pan, J Sun - Pharmacology & therapeutics, 2022 - Elsevier
Inflammatory bowel disease (IBD), comprised of ulcerative colitis and Crohn's disease, is a
chronic relapsing inflammatory disease of the gastrointestinal tract that closely related to …

The role of tissue-resident macrophages in the development and treatment of inflammatory bowel disease

S Ma, J Zhang, H Liu, S Li, Q Wang - Frontiers in cell and …, 2022 - frontiersin.org
Inflammatory bowel disease (IBD), comprising Crohn's disease and ulcerative colitis, is a
refractory disease with many immune abnormalities and pathologies in the gastrointestinal …

Macrophage–endothelial cell crosstalk orchestrates neutrophil recruitment in inflamed mucosa

X Ren, LD Manzanares, EB Piccolo… - The Journal of …, 2023 - Am Soc Clin Investig
Neutrophil (PMN) mobilization to sites of insult is critical for host defense and requires
transendothelial migration (TEM). TEM involves several well-studied sequential adhesive …

Bioengineering translational models of lymphoid tissues

YS Michaels, CF Buchanan, N Gjorevski… - Nature Reviews …, 2023 - nature.com
Bioengineered models of human tissues have the potential to revolutionize human health by
providing a translational platform to investigate disease mechanisms and develop new …

[HTML][HTML] A new face of old cells: An overview about the role of senescence and telomeres in inflammatory bowel diseases

M Sienkiewicz, K Sroka, A Binienda, D Jurk… - Ageing Research …, 2023 - Elsevier
Cellular senescence is a pivotal factor contributing to aging and the pathophysiology of age-
related diseases. Despite the presence of inflammation and abnormal immune system …

Mechanistic insights into the role of probiotics in modulating immune cells in ulcerative colitis

N Guo, L Lv - Immunity, Inflammation and Disease, 2023 - Wiley Online Library
Background Ulcerative colitis (UC) is a persistent inflammatory disorder that affects the
gastrointestinal tract, mainly the colon, which is defined by inflammatory responses and the …

The enteric nervous system

KA Sharkey, GM Mawe - Physiological reviews, 2023 - journals.physiology.org
Of all the organ systems in the body, the gastrointestinal tract is the most complicated in
terms of the numbers of structures involved, each with different functions, and the numbers …

[HTML][HTML] Inflammation and impaired gut physiology in post-operative ileus: mechanisms and the treatment options

Z Hussain, H Park - Journal of neurogastroenterology and motility, 2022 - ncbi.nlm.nih.gov
Post-operative ileus (POI) is the transient cessation of coordinated gastrointestinal motility
after abdominal surgical intervention. It decreases quality of life, prolongs length of hospital …

In Vitro Models for Investigating Intestinal Host–Pathogen Interactions

R McCoy, S Oldroyd, W Yang, K Wang… - Advanced …, 2024 - Wiley Online Library
Infectious diseases are increasingly recognized as a major threat worldwide due to the rise
of antimicrobial resistance and the emergence of novel pathogens. In vitro models that can …

Functional and Therapeutic Potential of Cynara scolymus in Health Benefits

C Porro, T Benameur, A Cianciulli, M Vacca, M Chiarini… - Nutrients, 2024 - mdpi.com
Dietary supplements enriched with bioactive compounds represent a promising approach to
influence physiological processes and enhance longevity and overall health. Cynara …