The tumour suppressor TP53 is a master regulator of several cellular processes that
collectively suppress tumorigenesis. The TP53 gene is mutated in~ 50% of human cancers …

Long known as digestive organelles, lysosomes have now emerged as multifaceted centers
responsible for degradation, nutrient sensing, and immunity. Growing evidence also …

Autophagy is a tightly regulated catabolic process that facilitates nutrient recycling from
damaged organelles and other cellular components through lysosomal degradation …

The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …

Radiation is a critical pillar in cancer therapeutics, exerting its anti-tumor DNA-damaging
effects through various direct and indirect mechanisms. Radiation has served as an effective …

Cisplatin has long been a first-line chemotherapeutic agent in the treatment of cancer,
largely for solid tumors. During the course of the past two decades, autophagy has been …

Autophagy is a conserved cellular process required to maintain homeostasis. The hallmark
of autophagy is the formation of a phagophore that engulfs cytosolic materials for …

Anti-estrogens or aromatase inhibitors in combination with cyclin-dependent kinase 4 and 6
(CDK4/6) inhibitors are the current standard of care for estrogen receptor-positive (ER+) Her …

Radiotherapy continues to be a primary modality in the treatment of cancer. In addition to
promoting apoptosis, radiation-induced DNA damage can promote autophagy and …

The manipulation of autophagy provides a new opportunity for highly effective anticancer
therapies. Recently, we showed that photodynamic therapy (PDT) with nitrogen‐doped …