Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by demyelination, with a relative sparing of axons. In MS patients, many …

Snakes of the Elapidae family (cobras, mambas and kraits) have venoms which contain
potent muscle-paralyzing toxins. These toxins are often referred to as' neurotoxins'. The …

Voltage-dependent cation channels are large heterooligomeric proteins. Heterologous
expression of cDNAs encoding the alpha subunits alone of K+, Na+, or Ca2+ channels …

The binding protein for the K+-channel toxin dendrotoxin I was purified from a detergent
extract of rat brain membranes. The purification procedure utilized chromatography on …

Potassium channels comprise groups of diverse proteins which can be distinguished
according to each member's biophysical properties. Some types of K+ channels are blocked …

Many venom toxins interfere with ion channel function. Toxins, as specific, high affinity
ligands, have played an important part in purifying and characterizing many ion channel …

Revised Manuscript Received August 3, 1992 abstract: Neuronal acceptors for a-
dendrotoxin (a-DTX) have recently been purified from mammalian brain and shown to …

Voltage-dependent ion channels are a difficult class of proteins to approach biochemically.
Many such channels are present at low density in relevant tissues and exist as multiple …

Subfamilies of voltage-activated K+ channels (Kv1-4) contribute to controlling neuron
excitability and the underlying functional parameters. Genes encoding the multiple α …

After the first detailed description of the delayed outward potassium current in squid axon by
Hodgkin and Huxley (1952) it took electrophysiologists more than 20 years to realize that in …