There is increasing evidence showing a close relationship between human radiation
sensitivity and age-related health effects including cancer. Individuals exposed to ionizing …

Background Mutations in the telomerase reverse transcriptase promoter (TERTp) region
have been associated with worse prognosis in some cancers. Meningiomas are the most …

Background and aims It has been established that endothelial senescence plays a critical
role in the development of atherosclerosis. Elevated S-adenosylhomocysteine (SAH) level …

Pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs), ESCs derived by
somatic cell nuclear transfer (ntESCs), and induced pluripotent stem cells (iPSCs) have …

With the increasing understanding of mesenchymal stem cells (MSCs), their potential in
tissue engineering and regenerative medicine has attracted more attention. However, some …

Telomeres comprise specialized nucleic acid–protein complexes that help protect
chromosome ends from DNA damage. Moreover, telomeres associate with subtelomeric …

Objective: This study aimed to explore the effect of silencing hTERT on the CSC-like
characteristics and radioresistance of CNE-2R cells. Results: Silencing hTERT suppressed …

Despite being an important diagnostic and treatment modality, ionizing radiation (IR) is also
known to cause genotoxicity and multiple side effects leading to secondary carcinogenesis …

Background Human telomerase reverse transcriptase (hTERT) is a crucial oncogene and a
key factor in cell immortalization. Apart from hematopoiesis stem cell and germ cells, normal …

Mesenchymal stem cells (MSCs) from bone marrow are capable of self-renewing and
multipotential differentiation. They can be greatly expanded in vitro and be induced to …