Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance
and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity …

CYP11A1 hydroxylates the side chain of vitamin D3 (D3) in a sequential fashion [D3→ 20S
(OH) D3→ 20, 23 (OH) 2 D3→ 17, 20, 23 (OH) 3 D3], in an alternative to the classical …

Introduction: Gliomas are considered the most malignant form of brain tumors, and ranked
among the most aggressive human cancers. Despite advance standard therapy the …

We investigated the protective effects of melatonin and its metabolites: 6‐hydroxymelatonin
(6‐OHM), N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine (AFMK), N‐acetylserotonin (NAS) …

Cisplatin is a highly-effective and widely-used chemotherapeutic agent that causes
ototoxicity in many patients. Pharmacogenomic studies of key genes controlling drug …

Glioblastoma Multiforme (GBM) continues to demand improved chemotherapeutic solutions.
In order to discover novel chemotherapeutic agents for GBM, we identified novel …

硫嘌呤类药物是急性淋巴细胞白血病(ALL) 治疗缓解期的常用化学治疗药物之一,
其在体内需经代谢转化成具有生物活性的巯基鸟嘌呤核苷酸, 发挥杀死肿瘤细胞的作用 …

For TPMT, we searched the PubMed database from 1966 to October 2012 for the original
guideline and then Oct 1, 2012 to June 6, 2017 for this guideline update for keywords …

The aim of this Doctoral Thesis was to investigate the interindividual variability of thiopurine
metabolism using immunological, molecular biology methods, and metabolic status in …

In recent years, the hepatotoxic potential of thiopurines, in particular 6-thioguanine (6-TG),
has been discussed in literature. However, cirrhosis was exceptionally reported. We report …