Interactome maps are valuable resources to elucidate protein function and disease
mechanisms. Here, we report on an interactome map that focuses on neurodegenerative …

Accumulating evidence suggests that the serum response factor (SRF) cofactor
megakaryoblastic leukemia (MKL)/myocardin-related transcription factor (MRTF) has critical …

Synapse-to-nucleus signaling is critical for converting signals received at synapses into
transcriptional programs essential for cognition, memory, and emotion. This neuronal …

Background Histone modification plays essential roles in hepatocellular carcinoma (HCC)
pathogenesis, but the regulatory mechanisms remain poorly understood. In this study, we …

Serum response factor (SRF) is a representative transcription factor that plays crucial roles
in various biological phenomena by regulating immediate early genes (IEGs) and genes …

Ten to 20% of western countries population suffers from major depression disorder (MDD).
Stressful life events represent the main environmental risk factor contributing to the onset of …

Serum response factor (SRF) is a major transcription factor that regulates the expression of
several plasticity-associated genes in the brain. Although the developmental expression of …

Evolutionary rescue can in theory help populations avoid extinction after abrupt
environmental change through the rapid evolution of advantageous traits that promote …

The expression of immediate early genes (IEG s) is thought to be an essential molecular
basis of neuronal plasticity for higher brain function. Many IEG s contain serum response …

Serum response factor (SRF) is a transcription factor that plays essential roles in multiple
brain functions in concert with SRF cofactors such as ternary complex factor (TCF) and …