Lipids are crucial components of cellular function owing to their role in membrane formation,
intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid …

Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …

Measuring forces inside cells is particularly challenging. With the development of
quantitative microscopy, fluorophores which allow the measurement of forces became highly …

Sarcopenia is characterized by decreased skeletal muscle mass and function with age.
Aged muscles have altered lipid compositions; however, the role and regulation of lipids are …

The network of proteins that orchestrate the distribution of cholesterol among cellular
organelles is not fully characterized. We previously proposed that oxysterol‐binding protein …

Endoplasmic reticulum (ER)‐localized enzymes synthesize the vast majority of cellular
lipids. The ER therefore has a major influence on cellular lipid biomass and balances the …

Membrane surface charge is critical for the transient, yet specific recruitment of proteins with
polybasic regions to certain organelles. In eukaryotes, the plasma membrane (PM) is the …

To maintain an asymmetric distribution of ions across membranes, protein pumps displace
ions against their concentration gradient by using chemical energy. Here, we describe a …

Chemical neurotransmission is the major mechanism of neuronal communication.
Neurotransmitters are released from secretory organelles, the synaptic vesicles (SVs) via …

Inflammasomes are multi‐protein complexes that regulate the cleavage of cysteine protease
caspase‐1, secretion of inflammatory cytokines, and induction of inflammatory cell death …