[HTML][HTML] Analysis of microbial compositions: a review of normalization and differential abundance analysis

H Lin, SD Peddada - NPJ biofilms and microbiomes, 2020 - nature.com
Increasingly, researchers are discovering associations between microbiome and a wide
range of human diseases such as obesity, inflammatory bowel diseases, HIV, and so on …

Shotgun metagenomics, from sampling to analysis

C Quince, AW Walker, JT Simpson, NJ Loman… - Nature …, 2017 - nature.com
Diverse microbial communities of bacteria, archaea, viruses and single-celled eukaryotes
have crucial roles in the environment and in human health. However, microbes are …

[HTML][HTML] Microbiome differential abundance methods produce different results across 38 datasets

JT Nearing, GM Douglas, MG Hayes… - Nature …, 2022 - nature.com
Identifying differentially abundant microbes is a common goal of microbiome studies.
Multiple methods are used interchangeably for this purpose in the literature. Yet, there are …

[HTML][HTML] Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial

M Reyman, MA Van Houten, RL Watson… - Nature …, 2022 - nature.com
Broad-spectrum antibiotics for suspected early-onset neonatal sepsis (sEONS) may have
pronounced effects on gut microbiome development and selection of antimicrobial …

microbiomeMarker: an R/Bioconductor package for microbiome marker identification and visualization

Y Cao, Q Dong, D Wang, P Zhang, Y Liu, C Niu - Bioinformatics, 2022 - academic.oup.com
Characterizing biomarkers based on microbiome profiles has great potential for translational
medicine and precision medicine. Here, we present microbiomeMarker, an R/Bioconductor …

microeco: an R package for data mining in microbial community ecology

C Liu, Y Cui, X Li, M Yao - FEMS microbiology ecology, 2021 - academic.oup.com
ABSTRACT A large amount of sequencing data is produced in microbial community ecology
studies using the high-throughput sequencing technique, especially amplicon-sequencing …

[HTML][HTML] Analysis of compositions of microbiomes with bias correction

H Lin, SD Peddada - Nature communications, 2020 - nature.com
Differential abundance (DA) analysis of microbiome data continues to be a challenging
problem due to the complexity of the data. In this article we define the notion of “sampling …

Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis

N Pernigoni, E Zagato, A Calcinotto, M Troiani… - Science, 2021 - science.org
The microbiota comprises the microorganisms that live in close contact with the host, with
mutual benefit for both counterparts. The contribution of the gut microbiota to the emergence …

[HTML][HTML] MicrobiotaProcess: A comprehensive R package for deep mining microbiome

S Xu, L Zhan, W Tang, Q Wang, Z Dai, L Zhou, T Feng… - The Innovation, 2023 - cell.com
The data output from microbiome research is growing at an accelerating rate, yet mining the
data quickly and efficiently remains difficult. There is still a lack of an effective data structure …

[HTML][HTML] Multivariable association discovery in population-scale meta-omics studies

H Mallick, A Rahnavard, LJ McIver, S Ma… - PLoS computational …, 2021 - journals.plos.org
It is challenging to associate features such as human health outcomes, diet, environmental
conditions, or other metadata to microbial community measurements, due in part to their …