Membrane targeting cationic antimicrobial peptides
Many short cationic peptides are amphiphilic and are often termed antimicrobial peptides
(AMPs) as they can kill various microorganisms. These AMPs have largely been discovered …
(AMPs) as they can kill various microorganisms. These AMPs have largely been discovered …
Design and use of model membranes to study biomolecular interactions using complementary surface-sensitive techniques
LA Clifton, RA Campbell, F Sebastiani… - Advances in Colloid and …, 2020 - Elsevier
Cellular membranes are complex structures and simplified analogues in the form of model
membranes or biomembranes are used as platforms to understand fundamental properties …
membranes or biomembranes are used as platforms to understand fundamental properties …
[HTML][HTML] Lipopolysaccharides at solid and liquid interfaces: models for biophysical studies of the gram-negative bacterial outer membrane
Lipopolysaccharides (LPSs) are a constitutive element of the cell envelope of Gram-
negative bacteria, representing the main lipid in the external leaflet of their outer membrane …
negative bacteria, representing the main lipid in the external leaflet of their outer membrane …
Structural disruptions of the outer membranes of gram-negative bacteria by rationally designed amphiphilic antimicrobial peptides
Gram-negative bacteria are covered by both an inner cytoplasmic membrane (IM) and an
outer membrane (OM). Antimicrobial peptides (AMPs) must first permeate through the OM …
outer membrane (OM). Antimicrobial peptides (AMPs) must first permeate through the OM …
Fundamentals on the molecular mechanism of action of antimicrobial peptides
JAF Corrêa, AG Evangelista, T de Melo Nazareth… - Materialia, 2019 - Elsevier
Antimicrobial peptides (AMPs) are produced by several organisms as their first line of
defense. Constituted by amino acids, they may present different mechanisms of action. The …
defense. Constituted by amino acids, they may present different mechanisms of action. The …
[HTML][HTML] Rationally designed short cationic α-helical peptides with selective anticancer activity
Hypothesis Naturally derived or synthetic anticancer peptides (ACPs) have emerged as a
new generation of anticancer agents with higher selectivity for cancer cells and less …
new generation of anticancer agents with higher selectivity for cancer cells and less …
[HTML][HTML] How do antimicrobial peptides disrupt the lipopolysaccharide membrane leaflet of Gram-negative bacteria?
Hypothesis: It is widely regarded that antimicrobial peptides (AMPs) kill bacteria by
physically disrupting microbial membranes and causing cytoplasmic leakage, but it remains …
physically disrupting microbial membranes and causing cytoplasmic leakage, but it remains …
Hydrophobic control of the bioactivity and cytotoxicity of de novo-designed antimicrobial peptides
Antimicrobial peptides (AMPs) can target bacterial membranes and kill bacteria through
membrane structural damage and cytoplasmic leakage. A group of surfactant-like cationic …
membrane structural damage and cytoplasmic leakage. A group of surfactant-like cationic …
Understanding the structure and dynamics of complex biomembrane interactions by neutron scattering techniques
The membrane is one of the key structural materials of biology at the cellular level.
Composed predominantly of a bilayer of lipids with embedded and bound proteins, it defines …
Composed predominantly of a bilayer of lipids with embedded and bound proteins, it defines …
Manufacturing drug co-loaded liposomal formulations targeting breast cancer: Influence of preparative method on liposomes characteristics and in vitro toxicity
L Gkionis, RA Campbell, H Aojula, LK Harris… - International journal of …, 2020 - Elsevier
Developing more efficient manufacturing methods for nano therapeutic systems is becoming
important, not only to better control their physico-chemical characteristics and therapeutic …
important, not only to better control their physico-chemical characteristics and therapeutic …