Protein design is a valuable tool for understanding the fundamental factors that dictate
protein structure and function. The field of protein design has seen significant progress over …

Many efforts are being made in the design and engineering of metalloenzymes with catalytic
properties fulfilling the needs of practical applications. Progress in this field has recently …

The binding and catalytic functions of proteins are generally mediated by a small number of
functional residues held in place by the overall protein structure. Here, we describe deep …

Salt bridges occur frequently in proteins, providing conformational specificity and
contributing to molecular recognition and catalysis. We present a comprehensive analysis of …

Artificial metalloenzymes combine the advantages of both natural enzymes and chemically
synthesized models, which have achieved significant progress in the last decade. This …

There is a general need for the engineering of protein-like molecules that organize into
geometrically specific superstructures on molecular surfaces, directing further …

Current approaches to de novo design of proteins harboring a desired binding or catalytic
motif require pre-specification of an overall fold or secondary structure composition, and …

Metalloenzymes efficiently catalyze some of the most important and difficult reactions in
nature. For many years, coordination chemists have effectively used small molecule models …

Diesel engines have advantages due to their potential for high fuel conversion efficiency.
However, it is necessary to reduce pollutant emissions, particularly NOx and soot to meet …

De novo proteins provide a unique opportunity to investigate the structure–function
relationships of metalloproteins in a minimal, well-defined and controlled scaffold. Here, we …