Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair.
It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA …

Many intrinsically disordered proteins (IDPs) may undergo liquid–liquid phase separation
(LLPS) and participate in the formation of membraneless organelles in the cell, thereby …

Molecular dynamics (MD) simulation is a valuable tool for characterizing the structural
dynamics of folded proteins and should be similarly applicable to disordered proteins and …

Multidomain proteins with flexible linkers and disordered regions play important roles in
many cellular processes, but characterizing their conformational ensembles is difficult. We …

The formation and viscoelastic properties of condensates of intrinsically disordered proteins
(IDPs) is dictated by amino acid sequence and solution conditions. Because of the …

A substantial portion of the proteome consists of intrinsically disordered regions (IDRs) that
do not fold into well-defined 3D structures yet perform numerous biological functions and are …

Coarse-grained molecular dynamics simulations are a useful tool to determine
conformational ensembles of proteins. Here, we show that the coarse-grained force field …

Many proteins contain more than one folded domain, and such modular multi‐domain
proteins help expand the functional repertoire of proteins. Because of their larger size and …

Proliferating cell nuclear antigen (PCNA) is a cellular hub in DNA metabolism and a
potential drug target. Its binding partners carry a short linear motif (SLiM) known as the …

Intrinsically disordered proteins (IDPs) play a critical role in many biological processes. Due
to the inherent structural flexibility of IDPs, experimental methods present significant …