Hypothermia therapy is an old and important method of neuroprotection. Until now, many
neurological diseases such as stroke, traumatic brain injury, intracranial pressure elevation …

Ischemia/reperfusion injury is a complex molecular cascade that causes deleterious cellular
damage and organ dysfunction. Stroke, sudden cardiac arrest, and acute myocardial …

Simple Summary Clear cell renal cell carcinoma (ccRCC) is characterized by a high rate of
cell proliferation and an extensive accumulation of lipids. Uncontrolled cell growth usually …

BACKGROUND We have previously shown that treatment with valproic acid (VPA)
decreases brain lesion size in swine models of traumatic brain injury (TBI) and controlled …

This study aimed to investigate the effects of targeted temperature management (TTM)
modulation on traumatic brain injury (TBI) and the involved mechanisms using quantitative …

BACKGROUND Hemorrhage is a leading preventable cause of death. Nonselective histone
deacetylase inhibitors (HDACIs), such as valproic acid (VPA), have been shown to improve …

Abstract Kidney cancer accounts for 2.5% of all cancers, with an annual global incidence of
almost 300,000 cases leading to 111,000 deaths. Approximately 85% of kidney tumors are …

Traumatic brain injury (TBI) is a leading cause of death in young adults, and effective
treatment strategies have the potential to save many lives. TBI results in coagulopathy …

BACKGROUND High doses of the histone deacetylase inhibitor valproic acid (VPA, 150–
400 mg/kg) improve outcomes in animal models of lethal insults. We are conducting a US …

BACKGROUND Nonselective histone deacetylase (pan-HDAC) inhibitors, such as valproic
acid (VPA), have demonstrated neuroprotective properties in trauma models. However …