1. ABSTRACT A large body of evidence points to the positive effects of dietary
supplementation of acetyl-L-carnitine (ALC). Its use has shown health benefits in …

Platinum-based anticancer drugs are a cornerstone of the current antineoplastic treatment.
However, their use is limited by the onset of peripheral nervous system dysfunction, which …

Hearing loss caused by aging, noise, cisplatin toxicity, or other insults affects 360 million
people worldwide, but there are no Food and Drug Administration–approved drugs to …

Pancreatic ductal adenocarcinoma (PDAC) exhibits distinct molecular subtypes:
classical/progenitor and basal-like/squamous. Our study aimed to identify genes contributing …

Objectives Cisplatin is an anti‐neoplastic agent treatment with which causes many side
effects including ototoxicity. The aim of this study was to investigate whether acetyl‐l …

Aim Cisplatin chemotherapy is associated with neurotoxicity, and oxidative stress might play
an important role in the pathogenesis. Mirtazapine may be a preventative agent via its less …

Radiation therapy is a key modality in the treatment of different cancer types. Fatigue is the
most common side effect of radiotherapy, while others include nausea, hair loss, skin …

Malignant cells have a demonstrably greater sensitivity to glucose deprivation-induced
cytotoxicity than normal cells (Biochem. J. 418: 29). This has been hypothesized to be due to …

In the last few years, cancer chemotherapy has been successfully employed in the treatment
of different types of human tumours. Unfortunately, the optimal clinical usefulness of this …

High-risk neuroblastoma requires surgical resection and multi-drug chemotherapy. This
study aimed to develop an extended release, implantable and degradable delivery system …