Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
Abstract High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine
glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal …
glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal …
Current perspectives on diffuse midline glioma and a different role for the immune microenvironment compared to glioblastoma
CJ Pachocki, EM Hol - Journal of neuroinflammation, 2022 - Springer
Diffuse midline glioma (DMG), formerly called diffuse intrinsic pontine glioma (DIPG), is a
high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only …
high-grade malignant pediatric brain tumor with a near-zero survival rate. To date, only …
Functionalized macrophage exosomes with panobinostat and PPM1D‐siRNA for diffuse intrinsic pontine gliomas therapy
S Shan, J Chen, Y Sun, Y Wang, B Xia, H Tan… - Advanced …, 2022 - Wiley Online Library
Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain tumor. Mutation of
p53‐induced protein phosphatase 1 (PPM1D) in DIPG cells promotes tumor cell …
p53‐induced protein phosphatase 1 (PPM1D) in DIPG cells promotes tumor cell …
Dual targeting of polyamine synthesis and uptake in diffuse intrinsic pontine gliomas
Diffuse intrinsic pontine glioma (DIPG) is an incurable malignant childhood brain tumor, with
no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small …
no active systemic therapies and a 5-year survival of less than 1%. Polyamines are small …
Molecular profiling of tumors of the brainstem by sequencing of CSF-derived circulating tumor DNA
Brainstem gliomas are molecularly heterogeneous diseases, many of which are difficult to
safely surgically resect and have limited treatment options due to their eloquent location …
safely surgically resect and have limited treatment options due to their eloquent location …
Upfront biology-guided therapy in diffuse intrinsic pontine glioma: therapeutic, molecular, and biomarker outcomes from PNOC003
Purpose: PNOC003 is a multicenter precision medicine trial for children and young adults
with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Patients and Methods: Patients …
with newly diagnosed diffuse intrinsic pontine glioma (DIPG). Patients and Methods: Patients …
[HTML][HTML] Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: a matched-cohort analysis on behalf of …
GO Janssens, L Gandola, S Bolle, H Mandeville… - European journal of …, 2017 - Elsevier
Background Overall survival (OS) of patients with diffuse intrinsic pontine glioma (DIPG) is
poor. The purpose of this study is to analyse benefit and toxicity of re-irradiation at first …
poor. The purpose of this study is to analyse benefit and toxicity of re-irradiation at first …
Treatment strategies in diffuse midline gliomas with the H3K27M mutation: the role of convection-enhanced delivery in overcoming anatomic challenges
Diffuse midline gliomas harboring the H3 K27M mutation—including the previously named
diffuse intrinsic pontine glioma (DIPG)—are lethal high-grade pediatric brain tumors that are …
diffuse intrinsic pontine glioma (DIPG)—are lethal high-grade pediatric brain tumors that are …
Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery
S Alli, CA Figueiredo, B Golbourn, N Sabha… - Journal of controlled …, 2018 - Elsevier
Abstract Magnetic Resonance Image-guided Focused Ultrasound (MRgFUS) has been used
to achieve transient blood brain barrier (BBB) opening without tissue injury. Delivery of a …
to achieve transient blood brain barrier (BBB) opening without tissue injury. Delivery of a …
Pediatric diffuse midline gliomas: an unfinished puzzle
V Di Ruscio, G Del Baldo, F Fabozzi, M Vinci… - Diagnostics, 2022 - mdpi.com
Diffuse midline glioma (DMG) is a heterogeneous group of aggressive pediatric brain tumors
with a fatal prognosis. The biological hallmark in the major part of the cases is H3K27 …
with a fatal prognosis. The biological hallmark in the major part of the cases is H3K27 …