The immune response during acute HIV-1 infection: clues for vaccine development
AJ McMichael, P Borrow, GD Tomaras… - Nature Reviews …, 2010 - nature.com
The early immune response to HIV-1 infection is likely to be an important factor in
determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies …
determining the clinical course of disease. Recent data indicate that the HIV-1 quasispecies …
[HTML][HTML] Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies
PD Kwong, JR Mascola - Immunity, 2012 - cell.com
Antibodies that neutralize diverse strains of HIV-1 develop in∼ 20% of HIV-1-infected
individuals, and isolation and structural characterization of these antibodies are revealing …
individuals, and isolation and structural characterization of these antibodies are revealing …
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
Abstract Characterization of human monoclonal antibodies is providing considerable insight
into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane …
into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane …
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
D Sok, MJ van Gils, M Pauthner… - Proceedings of the …, 2014 - National Acad Sciences
Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are
favored candidates for vaccine design and immunotherapy because of their great …
favored candidates for vaccine design and immunotherapy because of their great …
Broadly neutralizing antibody responses in a large longitudinal sub-Saharan HIV primary infection cohort
E Landais, X Huang, C Havenar-Daughton… - PLoS …, 2016 - journals.plos.org
Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a
protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has …
protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has …
Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning
PD Kwong, JR Mascola, GJ Nabel - Nature Reviews Immunology, 2013 - nature.com
The field of HIV-1 vaccine research has seen a renaissance with the identification of
antibodies that neutralize most circulating HIV-1 strains. An understanding of the structural …
antibodies that neutralize most circulating HIV-1 strains. An understanding of the structural …
Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 …
ABSTRACT A window of opportunity for immune responses to extinguish human
immunodeficiency virus type 1 (HIV-1) exists from the moment of transmission through …
immunodeficiency virus type 1 (HIV-1) exists from the moment of transmission through …
The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4+ T Cell Decline and High Viral Load during Acute Infection
An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals
is needed to guide vaccine design and immunization strategies. Here we used a large panel …
is needed to guide vaccine design and immunization strategies. Here we used a large panel …
Evolution of an HIV glycan–dependent broadly neutralizing antibody epitope through immune escape
Neutralizing antibodies are likely to play a crucial part in a preventative HIV-1 vaccine.
Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by vaccination have …
Although efforts to elicit broadly cross-neutralizing (BCN) antibodies by vaccination have …
Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection
DN Sather, J Armann, LK Ching, A Mavrantoni… - Journal of …, 2009 - Am Soc Microbiol
The characterization of the cross-reactive, or heterologous, neutralizing antibody responses
developed during human immunodeficiency virus type 1 (HIV-1) infection and the …
developed during human immunodeficiency virus type 1 (HIV-1) infection and the …