The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+)
currents contribute importantly to shaping the waveforms of action potentials, and several …

Shal-type (Kv4. x) K+ channels are expressed in a variety of tissue, with particularly high
levels in the brain and heart. These channels are the primary subunits that contribute to …

Recent advances in molecular biology have had a major impact on our understanding of the
biophysical and molecular properties of ion channels. This review is focused on cardiac …

The activity of dopaminergic (DA) substantia nigra (SN) neurons is essential for voluntary
movement control. An intrinsic pacemaker in DA SN neurons generates their tonic …

Rapidly activating and inactivating cardiac transient outward K+ currents, Ito, are expressed
in most mammalian cardiomyocytes, and contribute importantly to the early phase of action …

Human mesenchymal stem cells (hMSC) have gained considerable interest due to their
potential use for cell replacement therapy and tissue engineering. One strategy is to …

GY Oudit, Z. Kassiri, R. Sah, RJ Ramirez, C. Zobel and PH Backx. The Molecular Physiology
of the Cardiac Transient Outward Potassium Current (Ito) in Normal and Diseased …

The biophysical characteristics and α subunits underlying calcium-independent transient
outward potassium current (Ito) phenotypes expressed in ferret left ventricular epicardial (LV …

Presenilin (PS) genes linked to early-onset familial Alzheimer's disease encode polytopic
membrane proteins that are presumed to constitute the catalytic subunit of γ-secretase …