The hippocampus plays an important role in emotional and cognitive processing, and both
of these domains are affected in patients with major depressive disorder (MDD). Extensive …

Although major depressive disorder is primarily considered a mood disorder, depressed
patients commonly present with clinically significant cognitive dysfunction that may add to …

Diabetes mellitus and depressive disorders are both common chronic diseases that
increase functional disability and social burden. Cognitive impairment is a potentially …

Sodium butyrate (NaB) has exhibited neuroprotective activity. This study aimed to explore
that NaB exerts beneficial effects on chronic unpredictable mild stress (CUMS)-induced …

Chronic, unresolved stress is a major risk factor for the development of clinical depression.
While many preclinical models of stress-induced depression have been reported, the …

Cognitive disturbances are often reported as serious incapacitating symptoms by patients
suffering from major depressive disorders (MDDs). Such deficits have been observed in …

Klotho (KL) is a glycosyl hydrolase and aging-suppressor gene. Stress is a risk factor for
depression and anxiety, which are highly comorbid with each other. The aim of this study is …

Depression is one of the most common neuropsychiatric disorders and has been associated
with impaired cognition, as well as causing neuroendocrine systems and brain proteins …

Agomelatine, a novel antidepressant with established clinical efficacy, acts as an agonist of
melatonergic MT1 and MT2 receptors and as an antagonist of 5-HT2C receptors. The …

Morin hydrate (MH) is the major flavonoid constituent of Morus alba acclaimed to have
antioxidant, anti-inflammatory, anti-stress and neuroprotective properties. However, report …