The code and beyond: transcription regulation by the RNA polymerase II carboxy-terminal domain
KM Harlen, LS Churchman - Nature reviews Molecular cell biology, 2017 - nature.com
The carboxy-terminal domain (CTD) extends from the largest subunit of RNA polymerase II
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
(Pol II) as a long, repetitive and largely unstructured polypeptide chain. Throughout the …
The pol II CTD: new twists in the tail
J Zaborowska, S Egloff, S Murphy - Nature structural & molecular …, 2016 - nature.com
The C-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II comprises
conserved heptad repeats, and post-translational modification of the CTD regulates …
conserved heptad repeats, and post-translational modification of the CTD regulates …
Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis
Histone post-translational modifications are key gene expression regulators, but their rapid
dynamics during development remain difficult to capture. We applied a Fab-based live …
dynamics during development remain difficult to capture. We applied a Fab-based live …
The RNA polymerase II CTD: the increasing complexity of a low-complexity protein domain
The largest subunit of RNA polymerase II contains a C-terminal domain (CTD) that plays key
roles in coordinating transcription with co-transcriptional events. The heptapeptide repeats …
roles in coordinating transcription with co-transcriptional events. The heptapeptide repeats …
R-loops enhance polycomb repression at a subset of developmental regulator genes
R-loops are three-stranded nucleic acid structures that form during transcription, especially
over unmethylated CpG-rich promoters of active genes. In mouse embryonic stem cells …
over unmethylated CpG-rich promoters of active genes. In mouse embryonic stem cells …
WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks
P Caron, T Pankotai, WW Wiegant… - Genes & …, 2019 - genesdev.cshlp.org
DNA double-strand breaks (DSBs) at RNA polymerase II (RNAPII) transcribed genes lead to
inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a …
inhibition of transcription. The DNA-dependent protein kinase (DNA-PK) complex plays a …
Lysine methylation regulators moonlighting outside the epigenome
Landmark discoveries made nearly two decades ago identified known transcriptional
regulators as histone lysine methyltransferases. Since then, the field of lysine methylation …
regulators as histone lysine methyltransferases. Since then, the field of lysine methylation …
Phosphorylation induces sequence-specific conformational switches in the RNA polymerase II C-terminal domain
The carboxy-terminal domain (CTD) of the RNA polymerase II (Pol II) large subunit cycles
through phosphorylation states that correlate with progression through the transcription …
through phosphorylation states that correlate with progression through the transcription …
[HTML][HTML] Arginine citrullination at the C-terminal domain controls RNA polymerase II transcription
The post-translational modification of key residues at the C-terminal domain of RNA
polymerase II (RNAP2-CTD) coordinates transcription, splicing, and RNA processing by …
polymerase II (RNAP2-CTD) coordinates transcription, splicing, and RNA processing by …
Simplicity is the ultimate sophistication—crosstalk of post-translational modifications on the rna polymerase ii
The highly conserved C-terminal domain (CTD) of the largest subunit of RNA polymerase II
comprises a consensus heptad (Y 1 S 2 P 3 T 4 S 5 P 6 S 7) repeated multiple times …
comprises a consensus heptad (Y 1 S 2 P 3 T 4 S 5 P 6 S 7) repeated multiple times …