Adult hippocampal neurogenesis in aging and Alzheimer's disease
Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the
millions of affected individuals. Progressive memory impairment in AD patients is associated …
millions of affected individuals. Progressive memory impairment in AD patients is associated …
The dialogue between neuroinflammation and adult neurogenesis: mechanisms involved and alterations in neurological diseases
Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
Adult hippocampal neurogenesis and its role in Alzheimer's disease
Y Mu, FH Gage - Molecular neurodegeneration, 2011 - Springer
The hippocampus, a brain area critical for learning and memory, is especially vulnerable to
damage at early stages of Alzheimer's disease (AD). Emerging evidence has indicated that …
damage at early stages of Alzheimer's disease (AD). Emerging evidence has indicated that …
Neuroinflammation and neurogenesis in Alzheimer's disease and potential therapeutic approaches
In adult brain, new neurons are generated throughout adulthood in the subventricular zone
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …
and the dentate gyrus; this process is commonly known as adult neurogenesis. The …
Molecular mechanisms of neurodegeneration in Alzheimer's disease
L Crews, E Masliah - Human molecular genetics, 2010 - academic.oup.com
Alzheimer's disease (AD) is characterized by cognitive impairment, progressive
neurodegeneration and formation of amyloid-β (Aβ)-containing plaques and neurofibrillary …
neurodegeneration and formation of amyloid-β (Aβ)-containing plaques and neurofibrillary …
Enriched environments, experience-dependent plasticity and disorders of the nervous system
J Nithianantharajah, AJ Hannan - Nature Reviews Neuroscience, 2006 - nature.com
Behavioural, cellular and molecular studies have revealed significant effects of enriched
environments on rodents and other species, and provided new insights into mechanisms of …
environments on rodents and other species, and provided new insights into mechanisms of …
The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain
MM Varnum, T Ikezu - Archivum immunologiae et therapiae experimentalis, 2012 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
decline of cognitive function. There is no therapy that can halt or reverse its progression …
decline of cognitive function. There is no therapy that can halt or reverse its progression …
Neurogenesis and exercise: past and future directions
H Van Praag - Neuromolecular medicine, 2008 - Springer
Research in humans and animals has shown that exercise improves mood and cognition.
Physical activity also causes a robust increase in neurogenesis in the dentate gyrus of the …
Physical activity also causes a robust increase in neurogenesis in the dentate gyrus of the …
Mouse models of Alzheimer's disease
AM Hall, ED Roberson - Brain research bulletin, 2012 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia, affecting 35 million people
today. The search for new treatments is made ever more urgent by prospects for increasing …
today. The search for new treatments is made ever more urgent by prospects for increasing …
Neurodegenerative disease and adult neurogenesis
The generation and cell death of newly generated cells have critical roles in brain
development and maintenance in the embryonic and adult brain. Alterations in these …
development and maintenance in the embryonic and adult brain. Alterations in these …