Review on Alzheimer's disease: inhibition of amyloid beta and tau tangle formation

H Ashrafian, EH Zadeh, RH Khan - International journal of biological …, 2021 - Elsevier
It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …

Evaluation of peptide/protein self-assembly and aggregation by spectroscopic methods

MF Pignataro, MG Herrera, VI Dodero - Molecules, 2020 - mdpi.com
The self-assembly of proteins is an essential process for a variety of cellular functions
including cell respiration, mobility and division. On the other hand, protein or peptide …

Mechanistic link between vitamin B12 and Alzheimer's disease

AA Lauer, HS Grimm, B Apel, N Golobrodska, L Kruse… - Biomolecules, 2022 - mdpi.com
Alzheimer's disease (AD) is the most common form of dementia in the elderly population,
affecting over 55 million people worldwide. Histopathological hallmarks of this multifactorial …

Protein aggregation: from background to inhibition strategies

P Alam, K Siddiqi, SK Chturvedi, RH Khan - International journal of …, 2017 - Elsevier
The aggregation of specific proteins is hypothesized to cause several pathological
conditions, which are collectively known as amyloid disorders. The aggregation of peptides …

In vitro neuroprotective effects of naringenin nanoemulsion against β-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation

S Md, SY Gan, YH Haw, CL Ho, S Wong… - International Journal of …, 2018 - Elsevier
Alzheimer's disease (AD) is an increasingly prevalent neurological disorder of the central
nervous system. There is growing evidence that amyloidogenesis is a pathological hallmark …

Functionalised penetrating peptide-chondroitin sulphate‑gold nanoparticles: Synthesis, characterization, and applications as an anti-Alzheimer's disease drug

Y Feng, X Li, D Ji, J Tian, Q Peng, Y Shen… - International Journal of …, 2023 - Elsevier
The purpose of this study was to construct a transmembrane peptide-chondroitin sulphate‑
gold nanoparticle (TAT-CS@ Au) delivery system and investigate its activity as an anti …

Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity

P Alam, AZ Beg, MK Siddiqi, SK Chaturvedi… - Archives of biochemistry …, 2017 - Elsevier
Protein aggregation into oligomers and fibrils are associated with many human
pathophysiologies. Compounds that modulate protein aggregation and interact with …

[HTML][HTML] Transferrin-functionalized liposomes loaded with vitamin VB12 for Alzheimer's disease therapy

S Andrade, MJ Ramalho, JA Loureiro… - International Journal of …, 2022 - Elsevier
Despite the efforts of the pharmaceutical and research sectors, Alzheimer's disease (AD)
remains incurable, imposing the demand for new effective strategies. Vitamin B12 (VB12) …

Vitamin B12 Deficiency and the Nervous System: Beyond Metabolic Decompensation—Comparing Biological Models and Gaining New Insights into Molecular and …

AR Mathew, G Di Matteo, P La Rosa… - International Journal of …, 2024 - mdpi.com
Vitamin B12 (VitB12) is a micronutrient and acts as a cofactor for fundamental biochemical
reactions: the synthesis of succinyl-CoA from methylmalonyl-CoA and biotin, and the …

Role of aromatic amino acids in amyloid self-assembly

IM Stanković, S Niu, MB Hall, SD Zarić - International journal of biological …, 2020 - Elsevier
Amyloids are proteins of a cross-β structure found as deposits in several diseases and also
in normal tissues (nails, spider net, silk). Aromatic amino acids are frequently found in …