The potential of biologics for the treatment of asthma

G Pelaia, A Vatrella, R Maselli - Nature reviews Drug discovery, 2012 - nature.com
Recent advances in the knowledge of asthma pathobiology suggest that biological therapies
that target cytokines can be potentially useful for the treatment of this complex and …

Refractory asthma: mechanisms, targets, and therapy

JL Trevor, JS Deshane - Allergy, 2014 - Wiley Online Library
Asthma is a common medical condition affecting 300 million people worldwide. Airway
inflammation, smooth muscle bronchoconstriction leading to airflow obstruction, and mucous …

The inflammatory response in the pathogenesis of asthma

FT Ishmael - Journal of Osteopathic Medicine, 2011 - degruyter.com
The Inflammatory Response in the Pathogenesis of Asthma Skip to content Should you have
institutional access? Here's how to get it ... De Gruyter € EUR - Euro £ GBP - Pound $ USD …

Targeting interleukin-4 in asthma: lost in translation?

T Maes, GF Joos, GG Brusselle - American journal of respiratory cell …, 2012 - atsjournals.org
The first discovery that interleukin-4 (IL-4) is crucial in the development of allergic airway
inflammation originates from the early 1990s. Whereas initial studies in experimental animal …

Expression of IL-6, IL-10, IL-17 and IL-8 in the peri-implant crevicular fluid of patients with peri-implantitis

VO Severino, MH Napimoga, SA de Lima Pereira - Archives of oral biology, 2011 - Elsevier
OBJECTIVES: The aim of this study was to compare the levels of cytokines IL-6, IL-10 and IL-
17 and the chemokine IL-8 in the peri-implant crevicular fluid (PCF) between the group of …

T helper 17 cells in airway diseases: from laboratory bench to bedside

R Halwani, S Al-Muhsen, Q Hamid - Chest, 2013 - Elsevier
T helper 17 (Th17) cytokines are now widely believed to be critical for the regulation of
various chronic immune diseases. Investigations have revealed a significant role for IL-17 …

TH17 cells in asthma and inflammation

SJ Aujla, JF Alcorn - Biochimica et Biophysica Acta (BBA)-General …, 2011 - Elsevier
BACKGROUND: The chronic airway disease asthma causes significant burden to patients
as well as the healthcare system with limited options for prevention or cure. Inadequate …

Mind-body interactions in the regulation of airway inflammation in asthma: a PET study of acute and chronic stress

MA Rosenkranz, S Esnault, BT Christian… - Brain, behavior, and …, 2016 - Elsevier
Background Psychological stress has long been recognized as a contributing factor to
asthma symptom expression and disease progression. Yet, the neural mechanisms that …

The flavonoid cyanidin blocks binding of the cytokine interleukin-17A to the IL-17RA subunit to alleviate inflammation in vivo

C Liu, L Zhu, K Fukuda, S Ouyang, X Chen, C Wang… - Science …, 2017 - science.org
Cyanidin, a key flavonoid that is present in red berries and other fruits, attenuates the
development of several diseases, including asthma, diabetes, atherosclerosis, and cancer …

Therapeutic potential of plant-derived tannins in non-malignant respiratory diseases

S Rajasekaran, N Rajasekar, A Sivanantham - The Journal of Nutritional …, 2021 - Elsevier
Respiratory diseases are the major cause of human illness and death around the world.
Despite advances in detection and treatment, very few classes of safe and effective therapy …