The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …

Legumain (LGMN) has been demonstrated to be overexpressed not just in breast, prostatic,
and liver tumor cells, but also in the macrophages that compose the tumor …

In recent decades, dysregulation of proteases and atypical proteolysis have become
increasingly recognized as important hallmarks of cancer, driving community-wide efforts to …

Legumain is a lysosomal cysteine protease whose biological function remains poorly
defined. Legumain activity is up-regulated in most human cancers and inflammatory …

Background & Objectives: Chromatin structure is the single most important feature that
distinguishes a cancer cell from a normal cell histologically. Chromatin remodeling proteins …

Whereas protease inhibitors have been developed successfully against hypertension and
viral infections, they have failed thus far as cancer drugs. With advances in cancer profiling …

Peptide ligases expand the repertoire of genetically encoded protein architectures by
synthesizing new peptide bonds, energetically driven by ATP or NTPs. Here, we report the …

Secreted factors are a key component of stem cell niche and their dysregulation
compromises stem cell function. Legumain is a secreted cysteine protease involved in …