Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

Follicle dynamics and anovulation in polycystic ovary syndrome

S Franks, J Stark, K Hardy - Human reproduction update, 2008 - academic.oup.com
BACKGROUND Polycystic ovary syndrome (PCOS) is the commonest cause of anovulatory
infertility and menstrual cycle abnormalities, but the factors responsible for failure to select a …

Environmental factors, epigenetics, and developmental origin of reproductive disorders

SM Ho, A Cheong, MA Adgent, J Veevers… - Reproductive …, 2017 - Elsevier
Sex-specific differentiation, development, and function of the reproductive system are largely
dependent on steroid hormones. For this reason, developmental exposure to estrogenic and …

The role of steroids in follicular growth

AE Drummond - Reproductive biology and endocrinology, 2006 - Springer
The steroidogenic pathway within the ovary gives rise to progestins, androgens and
oestrogens, all of which act via specific nuclear receptors to regulate reproductive function …

Does size matter in females? An overview of the impact of the high variation in the ovarian reserve on ovarian function and fertility, utility of anti-Müllerian hormone as …

JJ Ireland, GW Smith, D Scheetz… - Reproduction …, 2010 - CSIRO Publishing
The mechanism whereby the inherently high variation in ovary size and the total number of
high-quality oocytes in ovaries (ovarian reserve) impact on ovarian function and fertility …

Maternal undernutrition in cows impairs ovarian and cardiovascular systems in their offspring

F Mossa, F Carter, SW Walsh, DA Kenny… - Biology of …, 2013 - academic.oup.com
Severe prenatal undernutrition is usually associated with low birth weights in offspring and
disorders including hypertension, obesity, and diabetes. Whether alterations in maternal …

Polycystic ovary syndrome and its developmental origins

DA Dumesic, DH Abbott, V Padmanabhan - Reviews in Endocrine and …, 2007 - Springer
The prenatal testosterone (T)-treated adult female rhesus monkey is one animal model of
polycystic ovary syndrome (PCOS) in women, with early prenatal T excess programming a …

Sheep models of polycystic ovary syndrome phenotype

V Padmanabhan, A Veiga-Lopez - Molecular and cellular endocrinology, 2013 - Elsevier
Polycystic ovary syndrome (PCOS) is a fertility disorder affecting 5–7% of reproductive-aged
women. Women with PCOS manifest both reproductive and metabolic defects. Several …

Maternal bisphenol-A levels at delivery: a looming problem?

V Padmanabhan, K Siefert, S Ransom… - Journal of …, 2008 - nature.com
Objective: The objective was to determine whether bisphenol-A (BPA) is found in maternal
circulation of pregnant women in the US population and is related to gestational length and …

Potential factors result in diminished ovarian reserve: A comprehensive review

Q Zhu, Y Li, J Ma, H Ma, X Liang - Journal of Ovarian Research, 2023 - Springer
The ovarian reserve is defined as the quantity of oocytes stored in the ovary or the number of
oocytes that can be recruited. Ovarian reserve can be affected by many factors, including …