Discovery of diverse CRISPR-Cas systems and expansion of the genome engineering toolbox
CRISPR systems mediate adaptive immunity in bacteria and archaea through diverse
effector mechanisms and have been repurposed for versatile applications in therapeutics …
effector mechanisms and have been repurposed for versatile applications in therapeutics …
Data Storage Using DNA
The exponential growth of global data has outpaced the storage capacities of current
technologies, necessitating innovative storage strategies. DNA, as a natural medium for …
technologies, necessitating innovative storage strategies. DNA, as a natural medium for …
A split and inducible adenine base editor for precise in vivo base editing
DNA base editors use deaminases fused to a programmable DNA-binding protein for
targeted nucleotide conversion. However, the most widely used TadA deaminases lack post …
targeted nucleotide conversion. However, the most widely used TadA deaminases lack post …
Reversing the central dogma: RNA-guided control of DNA in epigenetics and genome editing
Summary The Central Dogma of the flow of genetic information is arguably the crowning
achievement of 20 th century molecular biology. Reversing the flow of information from RNA …
achievement of 20 th century molecular biology. Reversing the flow of information from RNA …
[HTML][HTML] Molecular recording: transcriptional data collection into the genome
SK Lear, SL Shipman - Current opinion in biotechnology, 2023 - Elsevier
Highlights•Molecular recorders capture transcriptional activity within the genome of
cells.•Transcriptional activity is recorded by linking a signal of interest to a DNA …
cells.•Transcriptional activity is recorded by linking a signal of interest to a DNA …
[HTML][HTML] Advanced gene therapy system for the treatment of solid tumour: A review
Y Ma, J Liao, H Cheng, Q Yang, H Yang - Materials Today Bio, 2024 - Elsevier
In contrast to conventional therapies that require repeated dosing, gene therapy can treat
diseases by correcting defective genes after a single transfection and achieving cascade …
diseases by correcting defective genes after a single transfection and achieving cascade …
Nonspecific interactions between Cas12a and dsDNA located downstream of the PAM mediate target search and assist AsCas12a for DNA cleavage
Cas12a is one of the most commonly used Cas proteins for genome editing and gene
regulation. The first key step for Cas12a to fulfill its function is to search for its target among …
regulation. The first key step for Cas12a to fulfill its function is to search for its target among …
Sonogenetic control of multiplexed genome regulation and base editing
Manipulating gene expression in the host genome with high precision is crucial for
controlling cellular function and behavior. Here, we present a precise, non-invasive, and …
controlling cellular function and behavior. Here, we present a precise, non-invasive, and …
A DNA circuit that records molecular events
Characterizing the relative onset time, strength, and duration of molecular signals is critical
for understanding the operation of signal transduction and genetic regulatory networks …
for understanding the operation of signal transduction and genetic regulatory networks …
A CRISPR-Cas and Argonaute-Driven Two-Factor Authentication Strategy for Information Security
R Fu, J Hou, Z Wang, C Zhu, Y Xianyu - ACS nano, 2025 - ACS Publications
The escalating growth in computing power and the advent of quantum computing present a
critical threat to the security of modern cryptography. Two-factor authentication strategies …
critical threat to the security of modern cryptography. Two-factor authentication strategies …