Spirocyclic frameworks have attracted synthetic practitioners due to their unique three-
dimensional assembly, improved metabolic stability, solubility, and increased molecular …

Chiral polycyclic chromanones are important heterocyclic frameworks that constitute the
core structures of many natural products and bioactive molecules. As starting materials, the …

This review summarizes the latest developments in asymmetric domino reactions, with the
emphasis on the preparation of spiro compounds. Discussions on the stereoselectivity of the …

In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino
methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride as …

Summary β, γ-Unsaturated α-ketoesters prove to be versatile organic synthons participating
in diverse catalytic asymmetric transformations with the breathtaking development of organo …

Abstract A Lewis acid‐catalyzed (3+ 2) cycloaddition of 2‐indolylmethanols with β, γ‐
unsaturated α‐ketoesters was established, which afforded a series of cyclopenta [b] indoles …

This work describes a chiral bifunctional squaramide/DBU sequential catalytic strategy for
the enantioselective synthesis of nonfused chiral eight-membered O-heterocycles through …

Inspired by the chemistry and biology of fluorine-containing molecules and pyrrolidinyl
spirooxindoles, herein we report a highly diastereoselective [3+ 2] cycloaddition reaction of …

Enantioselective access to polycyclic tetrahydroxanthone compounds was achieved through
an organocatalyzed cascade reaction of alkene‐substituted 1, 3‐diketones and …

A set of cascade benzannulations of readily accessible chromone-3-carboxaldehydes and γ-
nitroaldehydes for synthesizing biologically relevant 2-hydroxybenzophenones has been …