Deep brain stimulation has been extensively studied as a therapeutic option for treatment-
resistant depression (TRD). DBS across different targets is associated with on average 60 …

Cerebral strokes can disrupt descending commands from motor cortical areas to the spinal
cord, which can result in permanent motor deficits of the arm and hand. However, below the …

The mapping of human brain connections is still an on going task. Unlike deep white matter
(DWM), which has been extensively studied and well documented, superficial white matter …

Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …

Diffusion-weighted magnetic resonance imaging (dMRI) is the primary method for
noninvasively studying the organization of white matter in the human brain. Here we …

A comprehensive map of the structural connectome in the human brain has been a coveted
resource for understanding macroscopic brain networks. Here we report an expert-vetted …

Cognitive function is driven by dynamic interactions between large-scale neural circuits or
networks, enabling behaviour. However, fundamental principles constraining these dynamic …

Encoding brain regions and their connections as a network of nodes and edges captures
many of the possible paths along which information can be transmitted as humans process …

Background Deep brain stimulation for obsessive-compulsive disorder is a rapidly
developing treatment strategy for treatment-refractory patients. Both the exact target and …

The ability to modulate brain states using targeted stimulation is increasingly being
employed to treat neurological disorders and to enhance human performance. Despite the …