Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate
endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite …

The human organic anion and cation transporters are classified within two SLC
superfamilies. Superfamily SLCO (formerly SLC21A) consists of organic anion transporting …

The blood-brain barrier (BBB) and blood-cerebrospinal fluid (BCSF) barriers are critical
determinants of CNS homeostasis. Additionally, the BBB and BCSF barriers are formidable …

This white paper provides a critical analysis of methods for estimating transporter kinetics
and recommendations on proper parameter calculation in various experimental systems …

Members of the solute carrier organic anion transporting polypeptide (OATPs) family
function as transporters for a large variety of amphipathic organic anions including …

This review addressed drug interactions precipitated by fruit juices other than grapefruit juice
based on randomized controlled trials (RCTs). Literature was identified by searching …

Organic anion-transporting polypeptides or OATPs are central transporters in the disposition
of drugs and other xenobiotics. In addition, they mediate transport of a wide variety of …

One approach to experimental science involves creating hypotheses, then testing them by
varying one or more independent variables, and assessing the effects of this variation on the …

Solute carrier (SLC) family transporters utilize an electrochemical potential difference or an
ion gradient generated by primary active transporters for transporting their substrates across …

Polypharmacy is often needed for the management of cardiovascular diseases and is
associated with poor adherence to treatment. Hence, highly flexible and adaptable systems …