Autism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by
deficits in social interaction skills, impaired communication, and repetitive and restricted …

Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

Atypical brain connectivity is a major contributor to the pathophysiology of
neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 …

Understanding the mechanisms underlying autism spectrum disorders (ASDs) is a
challenging goal. Here we review recent progress on several fronts, including genetics …

The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …

Protein synthesis in eukaryotic cells is a complex, multi-step and tightly regulated process.
Translation initiation, the rate limiting step in protein synthesis, is dependent on the activity of …

In long-term depression (LTD) at synapses in the adult brain, synaptic strength is reduced in
an experience-dependent manner. LTD thus provides a cellular mechanism for information …

Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that are
activated by glutamate in the central nervous system (CNS). Basically, mGluRs contribute to …

In multiple cell types, mRNAs are transported to subcellular compartments, where local
translation enables rapid, spatially localized, and specific responses to external stimuli …

Autism spectrum disorder (ASD) is typically characterized by common deficits in social skills
and repetitive/stereotyped behaviors. It is widely accepted that genetic and environmental …