Review of the current state of protein aggregation inhibition from a materials chemistry perspective: Special focus on polymeric materials
Protein instability caused by exposure to external additives or severe stress may result in
different diseases. Of these diseases, many are triggered by protein misfolding and …
different diseases. Of these diseases, many are triggered by protein misfolding and …
Translating therapeutic microgels into clinical applications
Y Kittel, AJC Kuehne… - Advanced Healthcare …, 2022 - Wiley Online Library
Microgels are crosslinked, water‐swollen networks with a 10 nm to 100 µm diameter and
can be modified chemically or biologically to render them biocompatible for advanced …
can be modified chemically or biologically to render them biocompatible for advanced …
Modulation of amyloid protein fibrillation by synthetic polymers: Recent advances in the context of neurodegenerative diseases
Protein misfolding and aggregation have attracted immense research interests due to their
connection with an array of degenerative diseases including neurodegenerative disorders …
connection with an array of degenerative diseases including neurodegenerative disorders …
Ascorbic acid inhibits human insulin aggregation and protects against amyloid induced cytotoxicity
Protein aggregation into oligomers and fibrils are associated with many human
pathophysiologies. Compounds that modulate protein aggregation and interact with …
pathophysiologies. Compounds that modulate protein aggregation and interact with …
Macromolecular cryoprotectants for the preservation of mammalian cell culture: lessons from crowding, overview and perspectives
Cryopreservation is a process used for the storage of mammalian cells at a very low
temperature, in a state of 'suspended animation.'Highly effective and safe macromolecular …
temperature, in a state of 'suspended animation.'Highly effective and safe macromolecular …
Toward a molecular understanding of the mechanism of cryopreservation by polyampholytes: cell membrane interactions and hydrophobicity
R Rajan, F Hayashi, T Nagashima… - …, 2016 - ACS Publications
Cryopreservation enables long-term preservation of cells at ultralow temperatures. Current
cryoprotective agents (CPAs) have several limitations, making it imperative to develop CPAs …
cryoprotective agents (CPAs) have several limitations, making it imperative to develop CPAs …
Stimuli-responsive zwitterionic core–shell microgels for antifouling surface coatings
Fouling on filtration membranes is induced by the nonspecific interactions between the
membrane surface and the foulants, and effectively hinders their efficient use in various …
membrane surface and the foulants, and effectively hinders their efficient use in various …
Facile photolithographic fabrication of zwitterionic polymer microneedles with protein aggregation inhibition for transdermal drug delivery
H Pitakjakpipop, R Rajan, K Tantisantisom… - …, 2021 - ACS Publications
Microneedle technology has received considerable attention in transdermal drug delivery
system research owing to its minimally invasive and convenient self-administration with …
system research owing to its minimally invasive and convenient self-administration with …
Polyampholyte‐Based Polymer Hydrogels for the Long‐Term Storage, Protection and Delivery of Therapeutic Proteins
Protein storage and delivery are crucial for biomedical applications such as protein
therapeutics and recombinant proteins. Lack of proper protocols results in the denaturation …
therapeutics and recombinant proteins. Lack of proper protocols results in the denaturation …
Ultrastable and Redispersible Zwitterionic Bottlebrush Micelles for Drug Delivery
Bottlebrush copolymers are increasingly used for drug delivery and biological imaging
applications in part due to the enhanced thermodynamic stability of their self-assemblies …
applications in part due to the enhanced thermodynamic stability of their self-assemblies …