Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

Depression is an episodic form of mental illness characterized by mood state transitions with
poorly understood neurobiological mechanisms. Antidepressants reverse the effects of …

Deep brain stimulation is a promising treatment for neuropsychiatric conditions such as
major depression. It could be optimized by identifying neural biomarkers that trigger therapy …

Neural recordings using invasive devices in humans can elucidate the circuits underlying
brain disorders, but have so far been limited to short recordings from externalized brain …

Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in
randomized trials raises questions regarding anatomical targeting. We implanted multi-site …

Responsive neurostimulation (RNS) devices, able to detect imminent seizures and to rapidly
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …

Brain–machine interfaces (BMIs) create closed-loop control systems that interact with the
brain by recording and modulating neural activity and aim to restore lost function, most …

Direct electrical stimulation can modulate the activity of brain networks for the treatment of
several neurological and neuropsychiatric disorders and for restoring lost function. However …

Major depressive disorder (MDD) is widely hypothesized to result from disordered
communication across brain-wide networks. Yet, prior resting-state-functional MRI (rs-fMRI) …

Affective experiences are commonly represented by either transient emotional reactions to
discrete events or longer term, sustained mood states that are characterized by a more …