Transfection is a modern and powerful method used to insert foreign nucleic acids into
eukaryotic cells. The ability to modify host cells' genetic content enables the broad …

Since its discovery, the CRISPR/Cas technology has rapidly become an essential tool in
modern biomedical research. The opportunities to specifically modify and correct genomic …

Liposomes are vesicular structures made of lipids that are formed in aqueous solutions.
Structurally, they resemble the lipid membrane of living cells. Therefore, they have been …

DNA is stored in vivo in a highly compact, so-called condensed phase, where gene
regulatory processes are governed by the intricate interplay between different states of DNA …

The gene delivery to skeletal muscles is a promising strategy for the treatment of both
muscular disorders (by silencing or overexpression of specific gene) and systemic secretion …

Targeted delivery of DNA nanoparticles is a promising approach in cancer therapy. Using
aptamers, target specific delivery of DNA nanoparticles can be achieved. Further, aptamers …

The most important objective of the present study was to explain why cationic lipid (CL)-
mediated delivery of plasmid DNA (pDNA) is better than that of linear DNA in gene therapy …

Inducer molecules capable of regulating mesenchymal stem cell differentiation into specific
lineages have proven effective in basic science and in preclinical studies. Runt-related …

The use of cationic lipids (CLs) as transfecting agents of DNA has received an increasing
attention in the last two decades. In order to improve the transfection efficiency with lower …

Extrachromosomal DNA (ecDNA) is circular DNA that plays an important role in the
development and heterogeneity of cancer. The rapid evolution of methods to detect ecDNA …