Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

The with no lysine (K)(WNK) kinases are an evolutionarily ancient group of kinases with
atypical placement of the catalytic lysine and diverse physiological roles. Recent studies …

Osteoclast over-activation leads to bone loss and chloride homeostasis is fundamental
importance for osteoclast function. The calcium-activated chloride channel Anoctamin 1 …

Abstract SARS-CoV-2, the culprit pathogen of COVID-19, elicits prominent immune
responses and cytokine storms. Intracellular Cl− is a crucial regulator of host defense …

Hypertension and atherosclerosis, the predecessors of stroke and myocardial infarction, are
chronic vascular inflammatory reactions. Tumor necrosis factor alpha (TNFα), the “master” …

Cystic fibrosis (CF) is a monogenetic disease resulting from mutations in the Cystic Fibrosis
Transmembrane conductance Regulator (CFTR) gene encoding an anion channel. Recent …

The activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome can be
induced by a wide spectrum of activators. This is unlikely achieved by the binding of different …

In the past decade, luminescent multimetallic transition metal complexes have become
indispensable tools in biology. They enable versatile applications, detecting biomolecules …

The relatively narrow spectrum of chemical elements within the microbial 'biochemical
palate'limits the reach of biotechnology, because several added-value compounds can only …

The role of Cl–as an intracellular signaling ion has been increasingly recognized in recent
years. One of the currently best described roles of Cl–in signaling is the modulation of the W …