Sirtuin 1 (SIRT1) regulates inflammation, aging (life span and health span), calorie
restriction/energetics, mitochondrial biogenesis, stress resistance, cellular senescence …

Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including
transcription factors thereby regulating metabolism, stress resistance, cellular survival …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Chronic obstructive pulmonary disease (COPD) is a major and increasing global health
problem that is now a leading cause of death. COPD is associated with a chronic …

Throughout the last 2 decades, experimental evidence from in vitro studies and preclinical
models of disease has demonstrated that reactive oxygen and nitrogen species, including …

A direct relationship exists between aging and increasing incidences of chronic diseases. In
fact, with most age-associated diseases individuals manifest an underlying chronic …

There is growing evidence for systemic inflammation in chronic obstructive pulmonary
disease (COPD). Increased circulating levels of inflammatory cytokines and acute phase …

Chronic obstructive pulmonary disease (COPD) is a progressive condition characterized by
airflow limitation associated with an abnormal inflammatory response of the lungs to noxious …

The respiratory system is continuously exposed to endogenous and exogenous oxidants.
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of …

Asthma and Chronic Obstructive Pulmonary Disease (COPD) are chronic obstructive
respiratory diseases characterized by airway obstruction, inflammation, and remodeling …