Hyaluronic acid-FGF2-derived peptide bioconjugates for suppression of FGFR2 and AR simultaneously as an acne antagonist

Z Su, Y Zhang, J Cao, Y Sun, Y Cai, B Zhang… - Journal of …, 2023 - Springer
Acne is a chronic skin condition that has serious consequences for mental and social well-
being because it frequently occurs on the face. Several acne treatment approaches have …

LINC00998‐encoded micropeptide SMIM30 promotes the G1/S transition of cell cycle by regulating cytosolic calcium level

JE Yang, WJ Zhong, JF Li, YY Lin, FT Liu… - Molecular …, 2023 - Wiley Online Library
The biological functions of short open reading frame (sORF)‐encoded micropeptides remain
largely unknown. Here, we report that LINC00998, a previously annotated lncRNA, was …

Synthesis and Evaluation of Novel 99mTc-Labeled FGFR2-Targeting Peptides

J Yao, M Fan, J Peng, H Luo, J Lu - Molecular Pharmaceutics, 2024 - ACS Publications
To develop radiolabeled FGFR2-targeting probes for visualizing fibroblast growth factor
receptor (FGFR) expression levels in the tumor microenvironment, four novel 99mTc-labeled …

OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2

Q Zhu, Y Fu, CP Cui, Y Ding, Z Deng, C Ning… - Signal transduction and …, 2023 - nature.com
Bone homeostasis is maintained by the balance between osteoblastic bone formation and
osteoclastic bone resorption. Dysregulation of this process leads to multiple diseases …

Structural optimization of fibroblast growth factor receptor inhibitors for treating solid tumors

C Li, Y Dai, X Kong, B Wang, X Peng… - Journal of Medicinal …, 2023 - ACS Publications
Small-molecule fibroblast growth factor receptor (FGFR) inhibitors have emerged as a
promising antitumor therapy. Herein, by further optimizing the lead compound 1 under the …

[HTML][HTML] An FGF2-Derived Short Peptide Attenuates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting Collagen Deposition and Epithelial–Mesenchymal Transition …

M Wang, Y Sun, Y Zhao, X Jiang, T Wang, J Xie… - International Journal of …, 2025 - mdpi.com
Following the COVID-19 pandemic, the prevalence of pulmonary fibrosis has increased
significantly, placing patients at higher risk and presenting new therapeutic challenges …

A PDX model combined with CD-DST assay to evaluate the antitumor properties of KRpep-2d and oxaliplatin in KRAS (G12D) mutant colorectal cancer

W Li, W Chen, J Wang, G Zhao, L Chen, Y Wan, Q Luo… - Heliyon, 2022 - cell.com
Patient-derived xenograft (PDX) models are more faithful in maintaining the characteristics
of human tumors than cell lines and are widely used in drug development, although they …

A Detection-Service-Mobile Three-Terminal Software Platform for Point-of-Care Infectious Disease Detection System

X Su, Y Fang, H Liu, Y Wang, M Ji, Z Chen, H Chen… - Biosensors, 2022 - mdpi.com
The traditional infectious disease detection process is cumbersome, and there is only a
single application scenario. In recent years, with the development of the medical industry …

'Renovation of old drugs'–can peptide drug conjugates lead the post-ADC era?

C Hao, P Chen, H Zhang… - Australian Journal of …, 2023 - CSIRO Publishing
Peptide–drug conjugates (PDCs) are an emerging targeted therapeutic drug following on
from the relative success of antibody–drug conjugates (ADCs). In this class, peptides are …