Internal senses of the vagus nerve

SL Prescott, SD Liberles - Neuron, 2022 - cell.com
The vagus nerve is an indispensable body-brain connection that controls vital aspects of
autonomic physiology like breathing, heart rate, blood pressure, and gut motility, reflexes …

Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health

A Parker, S Fonseca, SR Carding - Gut microbes, 2020 - Taylor & Francis
The human gastrointestinal (gut) microbiota comprises diverse and dynamic populations of
bacteria, archaea, viruses, fungi, and protozoa, coexisting in a mutualistic relationship with …

[HTML][HTML] The vagus nerve at the interface of the microbiota-gut-brain axis

B Bonaz, T Bazin, S Pellissier - Frontiers in neuroscience, 2018 - frontiersin.org
The microbiota, the gut, and the brain communicate through the microbiota-gut-brain axis in
a bidirectional way that involves the autonomic nervous system. The vagus nerve (VN), the …

Histamine production by the gut microbiota induces visceral hyperalgesia through histamine 4 receptor signaling in mice

G De Palma, C Shimbori, DE Reed, Y Yu… - Science Translational …, 2022 - science.org
The gut microbiota has been implicated in chronic pain disorders, including irritable bowel
syndrome (IBS), yet specific pathophysiological mechanisms remain unclear. We showed …

Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder

S Liu, E Li, Z Sun, D Fu, G Duan, M Jiang, Y Yu, L Mei… - Scientific reports, 2019 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by
impairments in social interactions and communication, restricted interests and repetitive …

[HTML][HTML] An atlas of vagal sensory neurons and their molecular specialization

J Kupari, M Häring, E Agirre, G Castelo-Branco… - Cell reports, 2019 - cell.com
Sensory functions of the vagus nerve are critical for conscious perceptions and for
monitoring visceral functions in the cardio-pulmonary and gastrointestinal systems. Here, we …

[HTML][HTML] Toward a wiring diagram understanding of appetite control

ML Andermann, BB Lowell - Neuron, 2017 - cell.com
Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …

Separate gut-brain circuits for fat and sugar reinforcement combine to promote overeating

M McDougle, A de Araujo, A Singh, M Yang, I Braga… - Cell metabolism, 2024 - cell.com
Food is a powerful natural reinforcer that guides feeding decisions. The vagus nerve
conveys internal sensory information from the gut to the brain about nutritional value; …

[HTML][HTML] Genetic identification of vagal sensory neurons that control feeding

L Bai, S Mesgarzadeh, KS Ramesh, EL Huey, Y Liu… - Cell, 2019 - cell.com
Energy homeostasis requires precise measurement of the quantity and quality of ingested
food. The vagus nerve innervates the gut and can detect diverse interoceptive cues, but the …

Sensory neurons that detect stretch and nutrients in the digestive system

EK Williams, RB Chang, DE Strochlic, BD Umans… - Cell, 2016 - cell.com
Neural inputs from internal organs are essential for normal autonomic function. The vagus
nerve is a key body-brain connection that monitors the digestive, cardiovascular, and …