Hypoxia-inducible factor 1α and its role in lung injury: adaptive or maladaptive

MV Suresh, S Balijepalli, S Solanki, S Aktay… - Inflammation, 2023 - Springer
Hypoxia-inducible factors (HIFs) are transcription factors critical for the adaptive response to
hypoxia. There is also an essential link between hypoxia and inflammation, and HIFs have …

Amphiregulin in infectious diseases: Role, mechanism, and potential therapeutic targets

CY Hsu, AF Mutee, S Porras, I Pineda, MA Mustafa… - Microbial …, 2024 - Elsevier
Amphiregulin (AREG) serves as a ligand for the epidermal growth factor receptor (EGFR)
and is involved in vital biological functions, including inflammatory responses, tissue …

[HTML][HTML] Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma

Z Liu, Y Wang, C Dou, M Xu, L Sun, L Wang, B Yao… - Theranostics, 2018 - ncbi.nlm.nih.gov
Rational: Patients with hepatocellular carcinoma (HCC) have a poor prognosis mostly due to
intrahepatic as well as distal metastasis. Vasodilator-stimulated phosphoprotein (VASP), a …

SH3BGRL2 inhibits growth and metastasis in clear cell renal cell carcinoma via activating hippo/TEAD1-Twist1 pathway

L Yin, W Li, A Xu, H Shi, K Wang, H Yang, R Wang… - …, 2020 - thelancet.com
Background Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent
malignancies in the world, and tumor metastasis is still the main reason for disease …

Liraglutide attenuates lipopolysaccharide-induced acute lung injury in mice

F Zhou, Y Zhang, J Chen, X Hu, Y Xu - European journal of pharmacology, 2016 - Elsevier
Liraglutide, an effective drug for the treatment of diabetes, has been proven to demonstrate
anti-inflammatory and immunomodulatory effects. Hence, this study explored the effects and …

AGK2 ameliorates mast cell-mediated allergic airway inflammation and fibrosis by inhibiting FcεRI/TGF-β signaling pathway

YY Kim, G Hur, SW Lee, SJ Lee, S Lee, SH Kim… - Pharmacological …, 2020 - Elsevier
Asthma is characterized by airway hyperresponsiveness and allergic inflammation,
detrimentally affecting the patients' quality of life. The development of new drugs for the …

HIF‑1α promotes NLRP3 inflammasome activation in bleomycin‑induced acute lung injury

JJ Huang, J Xia, LL Huang… - Molecular Medicine …, 2019 - spandidos-publications.com
The inflammatory response is one of the most important factors in the occurrence and
development of acute lung injury (ALI). Hypoxia‑inducible factor‑1α (HIF‑1α) and the NOD …

Saikosaponin A and its epimers alleviate LPS-induced acute lung injury in mice

D Peng, Y Chen, Y Sun, Z Zhang, N Cui, W Zhang, Y Qi… - Molecules, 2023 - mdpi.com
The purpose of this work was to illustrate the effect of processing with vinegar on
saikosaponins of Bupleurum chinense DC.(BC) and the protective effects of saikosaponin A …

Curcumin prophylaxis refurbishes alveolar epithelial barrier integrity and alveolar fluid clearance under hypoxia

M Titto, T Ankit, B Saumya, AK Gausal… - Respiratory physiology & …, 2020 - Elsevier
We have studied the prophylactic efficacy of curcumin to ameliorate the impairment of tight
junction protein integrity and fluid clearance in lungs of rats under hypoxia. A549 cells …

Silencing lncRNA SNHG6 suppresses proliferation and invasion of breast cancer cells through miR-26a/VASP axis

K Li, Y Ma, Y Tian, X Xu, Y Gao, Y He, W Pan… - … -Research and Practice, 2019 - Elsevier
The important role of LncRNA in the development of breast cancer is attracting more and
more attention. In the previous study, we found that the expression level of LncRNA SNHG6 …