Cardiac valves function in a mechanically complex environment, opening and closing close
to a billion times during the average human lifetime, experiencing transvalvular pressures …

Calcific aortic valve disease is dramatically increasing in global burden, yet no therapy
exists outside of prosthetic replacement. The increasing proportion of younger and more …

The aortic valve (AV) experiences a complex mechanical environment, which includes
tension, flexure, pressure, and shear stress forces due to blood flow during each cardiac …

The bicuspid aortic valve (BAV) is associated with a high prevalence of calcific aortic valve
disease (CAVD). Although abnormal hemodynamics has been proposed as a potential …

The bicuspid aortic valve (BAV) is the most common congenital cardiac anomaly and is
frequently associated with calcific aortic valve disease (CAVD). The most prevalent type-I …

The bicuspid aortic valve (BAV) is the most common congenital valvular defect and a major
risk factor for secondary calcific aortic valve disease. While hemodynamics is presumed to …

Calcific aortic valve disease (CAVD) is an active process presumably triggered by interplays
between cardiovascular risk factors, molecular signaling networks and hemodynamic cues …

The type-I bicuspid aortic valve (BAV), which differs from the normal tricuspid aortic valve
(TAV) most commonly by left-right coronary cusp fusion, is frequently associated with …

Aortic valve (AV) calcification is an inflammation driven process that occurs preferentially in
the fibrosa. To explore the underlying mechanisms, we investigated if key microRNAs …

The aortic valve (AV) achieves unidirectional blood flow between the left ventricle and the
aorta. Although hemodynamic stresses have been shown to regulate valvular biology, the …