Computational drug repositioning for chagas disease using protein-ligand interaction profiling

A Juárez-Saldivar, M Schroeder, S Salentin… - International journal of …, 2020 - mdpi.com
Chagas disease, caused by Trypanosoma cruzi (T. cruzi), affects nearly eight million people
worldwide. There are currently only limited treatment options, which cause several side …

NLRP3 inflammasome inhibitor glyburide expedites diabetic-induced impaired fracture healing

X Yang, C Qu, J Jia, Y Zhan - Immunobiology, 2019 - Elsevier
Localized inflammation is accompanied by the diabetic-induced fracture. The present study
aims to investigate the therapeutic effects of glyburide, an NLRP3 inflammasome inhibitor, in …

Ivermectin presents effective and selective antileishmanial activity in vitro and in vivo against Leishmania infantum and is therapeutic against visceral leishmaniasis

TAR Reis, JA Oliveira-da-Silva, GSV Tavares… - Experimental …, 2021 - Elsevier
Abstract Treatment for visceral leishmaniasis (VL) is hindered mainly by the toxicity and/or
high cost of therapeutic drugs. In addition, parasite resistance has been registered. Thus …

[HTML][HTML] In silico approaches supporting drug repurposing for Leishmaniasis: a scoping review

G Scheiffer, KZA Domingues, D Gorski… - EXCLI …, 2024 - pmc.ncbi.nlm.nih.gov
The shortage of treatment options for leishmaniasis, especially those easy to administer and
viable for deployment in the world's poorest regions, highlights the importance of employing …

Experimental and computational studies of novel Sudan-I dye modified conjugated oligomers: Efficient 1O2 generation and antileishmanial characteristics

N Singh, R Ali, SM Ashraf, A Rub, U Riaz - Materials Science and …, 2021 - Elsevier
Introduction of multi-functionality in conducting polymers via modification with dyes is a facile
technique that can be adopted to design various kinds of photosensitive and fluorescent …

[HTML][HTML] Repurposing the Antidiabetic Drugs Glyburide, Gliquidone, and Glipizide in Combination with Benznidazole for Trypanosoma cruzi Infection

C Vázquez, R Encalada, I Jiménez-Galicia… - Pharmaceuticals, 2024 - mdpi.com
Infection with the protozoan parasite Trypanosoma cruzi causes human Chagas disease.
Benznidazole (BNZ) and nifurtimox are the current drugs for the treatment; however, they …

Polyamine and trypanothione pathways as targets for novel antileishmanial drugs

IA Rodrigues, AR Garcia, MM Paz… - … Drug Development and …, 2021 - Springer
Leishmaniasis is an infectious disease classified by WHO as one of the neglected tropical
diseases. Due to the lack of human vaccines, chemotherapeutic agents represent the only …

Advances in Antileishmanial Chemotherapy

S Shuhail, S Das, T Datta, P Tyagi, M Tasleem… - … and Solutions Against …, 2024 - Springer
Leishmaniasis, an endemic tropical ailment, has invariably been categorized as one of the
“neglected tropical diseases” and is constantly linked with poverty. However, under current …