Pituitary adenomas are one of the most frequent intracranial tumors and occur with a
prevalence of approximately 1: 1000 in the developed world. Pituitary adenomas have a …

cAMP is a second messenger that controls many key cellular functions. The only way to
inactivate cAMP is to degrade it through the action of cAMP phosphodiesterases (PDEs) …

Low-intensity resistance exercise training combined with blood flow restriction (REFR)
increases muscle size and strength as much as conventional resistance exercise with high …

In the five decades that have elapsed since the identification of the second messenger
cAMP, most of the components involved in this signaling pathway have been identified, and …

Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of
metallophosphohydrolases that specifically cleave the 3′, 5′-cyclic phosphate moiety of …

In recent years, significant progress has been made in elucidating the signaling pathways
activated by the growth hormone (GH) receptor. An initiating event is probably the activation …

Cardiac myocytes have provided a key paradigm for the concept of the compartmentalized
cAMP generation sensed by AKAP-anchored PKA. Phosphodiesterases (PDEs) provide the …

Cyclic-3′, 5′-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology
of the kidney. Investigations of recent years revealed that isozymes of cyclic-3′, 5 …

Rapid progress has been made recently in the definition of growth hormone (GH) receptor
signal transduction pathways. It is now apparent that many cytokines, including GH, share …

The extracellular receptor stimulated kinase ERK2 (p42 MAPK)-phosphorylated human
cAMP-specific phosphodiesterase PDE4D3 at Ser579 and profoundly reduced (∼ 75%) its …