The secretion profile of mesenchymal stem cells and potential applications in treating human diseases
Y Han, J Yang, J Fang, Y Zhou, E Candi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …
Current and emerging therapies for corneal neovascularization
The cornea is unique because of its complete avascularity. Corneal neovascularization
(CNV) can result from a variety of etiologies including contact lens wear; corneal infections; …
(CNV) can result from a variety of etiologies including contact lens wear; corneal infections; …
Effect of human corneal mesenchymal stromal cell-derived exosomes on corneal epithelial wound healing
Purpose: Mesenchymal stromal cells (MSCs) have been used therapeutically to modulate
inflammation and promote repair. Extracellular vesicles, including exosomes, have been …
inflammation and promote repair. Extracellular vesicles, including exosomes, have been …
Characterizing the impact of 2D and 3D culture conditions on the therapeutic effects of human mesenchymal stem cell secretome on corneal wound healing in vitro …
K Carter, HJ Lee, KS Na, GM Fernandes-Cunha… - Acta biomaterialia, 2019 - Elsevier
The therapeutic effects of secreted factors (secretome) produced by bone marrow-derived
human mesenchymal stem cells (MSCs) were evaluated as a function of their growth in 2D …
human mesenchymal stem cells (MSCs) were evaluated as a function of their growth in 2D …
In vitro modeling of solid tumor interactions with perfused blood vessels
Molecular crosstalk between intra-tumor blood vessels and tumor cells plays many critical
roles in tumorigenesis and cancer metastasis. However, it has been very difficult to …
roles in tumorigenesis and cancer metastasis. However, it has been very difficult to …
Bone marrow mesenchymal stromal cells in a 3D system produce higher concentration of extracellular vesicles (EVs) with increased complexity and enhanced …
E Jalilian, H Massoumi, B Bigit, S Amin, EA Katz… - Stem Cell Research & …, 2022 - Springer
Abstract Purpose Extracellular vesicles (EVs) derived from mesenchymal stromal cells
(MSCs) have been demonstrated to possess great potential in preclinical models. An …
(MSCs) have been demonstrated to possess great potential in preclinical models. An …
Corneal wound healing effects of mesenchymal stem cell secretome delivered within a viscoelastic gel carrier
GM Fernandes-Cunha, KS Na, I Putra… - Stem cells …, 2019 - academic.oup.com
Severe corneal injuries often result in permanent vision loss and remain a clinical challenge.
Human bone marrow-derived mesenchymal stem cells (MSCs) and their secreted factors …
Human bone marrow-derived mesenchymal stem cells (MSCs) and their secreted factors …
Current and emerging therapies for limbal stem cell deficiency
The corneal epithelium serves to protect the underlying cornea from the external
environment and is essential for corneal transparency and optimal visual function …
environment and is essential for corneal transparency and optimal visual function …
Strategies for reconstructing the limbal stem cell niche
G Yazdanpanah, Z Haq, K Kang, S Jabbehdari… - The ocular …, 2019 - Elsevier
The epithelial cell layer that covers the surface of the cornea provides a protective barrier
while maintaining corneal transparency. The rapid and effective turnover of these epithelial …
while maintaining corneal transparency. The rapid and effective turnover of these epithelial …
Therapeutic efficacy of different routes of mesenchymal stem cell administration in corneal injury
Purpose Corneal injuries are associated with significant impairment in vision. Mesenchymal
stem cells (MSCs) have been shown to limit inflammation and promote tissue repair at the …
stem cells (MSCs) have been shown to limit inflammation and promote tissue repair at the …