ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and
nucleic acids, that regulates various cellular functions in all kingdoms of life. The recent …

Poly (ADP-ribose) is a posttranslational modification and signaling molecule that regulates
many aspects of human cell biology, and it is synthesized by enzymes known as poly (ADP …

Selective inhibitors of PARP1 and PARP2 (PARP1/2) are used to treat cancer patients with
deficiencies in the repair of DNA via homologous recombination. Here we provide a …

DNA double-strand breaks (DSBs) are repaired at DSB sites. How DSB sites assemble and
how broken DNA is prevented from separating is not understood. Here we uncover that the …

PARP inhibitors (PARPi) have emerged as promising cancer therapeutics capable of
targeting specific DNA repair pathways, but their mechanism of action with respect to PARP1 …

PARP1 rapidly detects DNA strand break damage and allosterically signals break detection
to the PARP1 catalytic domain to activate poly (ADP-ribose) production from NAD+. PARP1 …

PARP1 is a key player in the response to DNA damage and is the target of clinical inhibitors
for the treatment of cancers. Binding of PARP1 to damaged DNA leads to activation wherein …

Genome integrity is under constant insult from endogenous and exogenous sources. In
order to cope, eukaryotic cells have evolved an elaborate network of DNA repair that can …

DNA damage response (DDR) deficiencies result in genome instability, which is one of the
hallmarks of cancer. Poly (ADP-ribose) polymerase (PARP) enzymes take part in various …

Magnaporthe oryzae is a devastating fungal pathogen that causes the rice blast disease
worldwide. The post-translational modification of ADP-ribosylation holds significant …