The contribution of the nucleolus to cancer is well established with respect to its traditional
role in facilitating ribosome biogenesis and proliferative capacity. More contemporary …

The nucleolus represents a highly multifunctional intranuclear organelle in which, in addition
to the canonical ribosome assembly, numerous processes such as transcription, DNA repair …

The rates of ribosome production by a nucleolus and of protein biosynthesis by ribosomes
are tightly correlated with the rate of cell growth and proliferation. All these processes must …

Discovered in 1973, nucleolin is one of the most abundant phosphoproteins of the
nucleolus. The ability of nucleolin to be involved in many cellular processes is probably …

Long non-coding RNAs (lncRNAs), which are extensively transcribed from the genome,
have been proposed to be key regulators of diverse biological processes. However, little is …

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules consisting of
two ligands joined by a linker, enabling them to simultaneously bind with an E3 ligase and a …

p53 is possibly the most important mammalian tumor suppressor and it is mutated or lost in
more than half of all human cancers. The stability of p53 is primarily determined by the RING …

Fibroblast growth factors 1 and 2 (FGF1 and FGF2) are mainly considered as ligands of
surface receptors through which they regulate a broad spectrum of biological processes …

Mitochondria are intracellular organelles that are instrumental in the creation of energy,
metabolism, apoptosis, and intrinsic immunity. Mitochondria exhibit an extraordinarily high …

ErbB2, a member of the ErbB family of receptor tyrosine kinases, is an essential player in the
cell's growth and proliferation signaling pathways. Amplification or overexpression of ErbB2 …