Proton-pumping NADH: ubiquinone oxidoreductase (complex I) is the largest and most
complicated enzyme of the respiratory chain. Fourteen central subunits represent the …

Complex I (NADH: ubiquinone oxidoreductase) is the largest multimeric enzyme complex of
the mitochondrial respiratory chain, which is responsible for electron transport and the …

Dr. Harris has played a major role in the development of this organism as a model system.
Her previous version of the Chlamydomonas Sourcebook which published in 1989, has …

NADH: quinone oxidoreductase (complex I) pumps protons across the inner membrane of
mitochondria or the plasma membrane of many bacteria. Human complex I is involved in …

Isolated complex I deficiency is the most common cause of respiratory chain dysfunction.
Defects in human complex I result in energy generation disorders and they are also …

In photosynthetic eukaryotes, nonphotochemical plastoquinone (PQ) reduction is important
for the regulation of photosynthetic electron flow. In green microalgae where this process …

Abstract Sporadic cases account for 90–95% of all patients with Parkinson's Disease (PD).
Atypical Parkinsonism comprises approximately 20% of all patients with parkinsonism …

Diabetic retinopathy does not halt after hyperglycemia is terminated; the retina continues to
experience increased oxidative stress, suggesting a memory phenomenon. Mitochondrial …

Complex I deficiency, the most common respiratory chain defect, is genetically
heterogeneous: mutations in 8 nuclear and 7 mitochondrial DNA genes encoding complex I …

Mitochondrial transformation of Chlamydomonas reinhardtii has been optimized by using a
particle-gun device and cloned mitochondrial DNA or PCR fragments. A respiratory-deficient …