Serial femtosecond crystallography (SFX) revolutionized macromolecular crystallography
over the past decade by enabling the collection of X-ray diffraction data from nano-or …

Abstract The coronavirus disease 2019 (COVID-19) pandemic has had a major impact on
human life. This review highlights the versatile roles of both classical and modern structure …

Coronavirus endoribonuclease Nsp15 contributes to the evasion of host innate immunity by
suppressing levels of viral dsRNA. Nsp15 cleaves both ssRNA and dsRNA in vitro with a …

Droplet injection strategies are a promising tool to reduce the large amount of sample
consumed in serial femtosecond crystallography (SFX) measurements at X-ray free electron …

Understanding the functional properties of severe acute respiratory syndrome coronavirus 2
nonstructural proteins is essential for defining their roles in the viral life cycle, developing …

Coronaviruses evade detection by the host immune system with the help of the
endoribonuclease Nsp15, which regulates levels of viral double stranded RNA by cleaving …

Over the past two decades, serial X-ray crystallography has enabled the structure
determination of a wide range of proteins. With the advent of X-ray free-electron lasers …

With advances in X-ray free-electron lasers (XFELs), serial femtosecond crystallography
(SFX) has enabled the static and dynamic structure determination for challenging proteins …

Data collection at X-ray free electron lasers has particular experimental challenges, such as
continuous sample delivery or the use of novel ultrafast high-dynamic-range gain-switching …

Biophysical techniques include various methodologies applied in studying biological
systems at the molecular and cellular level for the drug discovery process. Various methods …